DegronMD

Uniprot ID: Q9H299

Source protein: SH3 domain-binding glutamic acid-rich-like protein 3

Source gene: SH3BGRL3

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.638

ASA_SCORE: 17.6

COIL: 0.215

CONS_SCORE: 0.7858

DSS_SCORE: 0.5497

HELIX: 0.0162

FCONS_SCORE: 1.0463

RIG_SCORE: 0.7614

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T9A	DO229248	THCA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.7139
p.T12I	SIDM01314	Colorectal Carcinoma	GDSC	VYSTS	DEG_SPOP_SBC_1	0.2778
p.S14Y	DO23426	LINC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z794	Keratin, type II cytoskeletal 1b	DEG_SPOP_SBC_1	18:22	VYSTS	SPOP	0.7206	More...
O95171	Sciellin	DEG_SPOP_SBC_1	607:611	VYSTS	SPOP	0.931	More...
Q9H299	SH3 domain-binding glutamic acid-rich-like protein 3	DEG_SPOP_SBC_1	6:10	VYSTS	SPOP	0.638	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons