DegronMD

Uniprot ID: Q7Z794

Source protein: Keratin, type II cytoskeletal 1b

Source gene: KRT77

Class: DEG_SPOP_SBC_1

Location: 202:206

E3 ligase: SPOP

DEGRON score: 0.7185

ASA_SCORE: 88.6

COIL: 0.9198

CONS_SCORE: 0.4112

DSS_SCORE: 0.3199

HELIX: 0.0586

FCONS_SCORE: 0.7675

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E212D	TCGA-EY-A1G8	UCEC	TCGA	VNTST	DEG_SPOP_SBC_1	0.1667
p.E212D	DO43578	UCEC	ICGC	VNTST	DEG_SPOP_SBC_1	0.1667
p.S205L	DO1071	BRCA	ICGC	VNTST	DEG_SPOP_SBC_1	0.7667
p.L192I	DO229015	LICA	ICGC	VNTST	DEG_SPOP_SBC_1	0.0556
p.T208N	SIDM00357	Small Cell Lung Carcinoma	GDSC	VNTST	DEG_SPOP_SBC_1	0.2778
p.T208N	SIDM00566	Oral Cavity Carcinoma	GDSC	VNTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z794	Keratin, type II cytoskeletal 1b	DEG_SPOP_SBC_1	202:206	VNTST	SPOP	0.7185	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons