DegronMD

Uniprot ID: O95171

Source protein: Sciellin

Source gene: SCEL

Class: LIG_APCC_ABBAyCdc20_2

Location: 215:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9106

ASA_SCORE: 94.3286

COIL: 0.8343

CONS_SCORE: 0.5099

DSS_SCORE: 0.7353

HELIX: 0.0204

FCONS_SCORE: 1.048

RIG_SCORE: 0.6542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q210H	TCGA-17-Z026	LUAD	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R228I	TCGA-E6-A1LX	UCEC	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R228I	DO41020	UCEC	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R224K	TCGA-FS-A4FD	SKCM	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.R224K	DO37699	SKCM	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.S225F	DO233634	GACA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P216S	DO50927	LICA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P213S	DO220878	MELA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E221G	SIDM00337	Melanoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00195	Ewing's Sarcoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00177	Melanoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00312	Plasma Cell Myeloma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E221G	SIDM01504	Small Cell Lung Carcinoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.7199
p.I211M	SIDM00575	Glioma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I211M	ACH-000200	Brain Cancer	CCLE	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I211M	NMC-G1	central_nervous_system	COSMIC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S231R	LoVo	large_intestine	COSMIC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95171	Sciellin	LIG_APCC_ABBAyCdc20_2	215:221	KPGVYTE	APC,CDC20,FZR1	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons