DegronMD - Q9UHJ3(SFMBT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V676I	TCGA-96-8169	LUSC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0556
p.V676I	DO26737	LUSC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0556
p.R681C	TCGA-AP-A051	UCEC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.R681C	TCGA-AX-A2HC	UCEC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.R681C	DO41572	UCEC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.R681C	DO42673	UCEC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.R681C	SIDM00500	Colorectal Carcinoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.R681C	ACH-000959	Colon/Colorectal Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.I345T	TCGA-AX-A05S	UCEC	TCGA	PPGY	ITCH	348:351	Mutation rewiring degron network	0.25
p.I345T	DO43218	UCEC	ICGC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.25
p.K340N	TCGA-AX-A05Z	UCEC	TCGA	PPGY	ITCH	348:351	Mutation substituting flanking lysine	0.2222
p.K340N	DO40884	UCEC	ICGC	PPGY	ITCH	348:351	Mutation substituting flanking lysine	0.2222
p.K678R	TCGA-BR-8680	STAD	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation substituting flanking lysine	0.2222
p.K678R	DO47769	STAD	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation substituting flanking lysine	0.2222
p.C374Y	TCGA-DF-A2KN	UCEC	TCGA	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.0556
p.C374Y	DO223282	UCEC	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.0556
p.L343I	TCGA-DF-A2KU	UCEC	TCGA	PPGY	ITCH	348:351	Mutation rewiring degron network	0.1944
p.L343I	DO223286	UCEC	ICGC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.1944
p.E702K	TCGA-IR-A3LL	CESC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.E702K	DO44362	CESC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.E391K	TCGA-W3-AA1V	SKCM	TCGA	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.25
p.E391K	DO51276	SKCM	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.25
p.A691V	DO233766	GACA	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.5825
p.A691V	SIDM00910	Neuroblastoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.5825
p.A691V	ACH-000120	Neuroblastoma	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.5825
p.A691V	CHP-212	autonomic ganglia	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.5825
p.A691E	DO228948	LICA	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.659
p.H382N	DO228971	LICA	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.2778
p.H382N	DO229038	LICA	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.2778
p.P377L	DO231628	LINC	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.1389
p.P690A	DO231179	LUSC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.7503
p.P376S	DO220899	MELA	ICGC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation rewiring degron network	0.1111
p.K340T	DO50685	ORCA	ICGC	PPGY	ITCH	348:351	Mutation substituting flanking lysine	0.2222
p.G342S	DO229250	THCA	ICGC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.1667
p.P352Q	DO221044	WT	ICGC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.3056
p.H677Y	SIDM00663	Melanoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.H677Y	ACH-000814	Skin Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.H677Y	Hs939-T	skin	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.M388L	SIDM00177	Melanoma	GDSC	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation altering degron motif	0.5999
p.M388L	ACH-002338	Skin Cancer	CCLE	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation altering degron motif	0.5999
p.M388L	ACH-002510	Skin Cancer	CCLE	FKENM	DEG_APCC_KENBOX_2	384:388	Mutation altering degron motif	0.5999
p.G692D	SIDM00217	Colorectal Carcinoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.6087
p.G692D	ACH-000999	Colon/Colorectal Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.6087
p.G692D	SNU-1040	large intestine	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.6087
p.H344Y	SIDM00677	Colorectal Carcinoma	GDSC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.2222
p.H344Y	ACH-000007	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	348:351	Mutation rewiring degron network	0.2222
p.H344Y	LS-513	large intestine	COSMIC	PPGY	ITCH	348:351	Mutation rewiring degron network	0.2222

Kaplan plot for SFMBT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SFMBT1

UniProt ID: Q9UHJ3

Entrez ID: 51460

Protein name: Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SFMBT1 in