DegronMD

Uniprot ID: Q9UHJ3

Source protein: Scm-like with four MBT domains protein 1

Source gene: SFMBT1

Class: DEG_APCC_KENBOX_2

Location: 384:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6089

ASA_SCORE: 81.58

COIL: 0.8374

CONS_SCORE: 0.5958

DSS_SCORE: 0.2286

HELIX: 0.0242

FCONS_SCORE: 1.168

RIG_SCORE: 0.8029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C374Y	TCGA-DF-A2KN	UCEC	TCGA	FKENM	DEG_APCC_KENBOX_2	0.0556
p.C374Y	DO223282	UCEC	ICGC	FKENM	DEG_APCC_KENBOX_2	0.0556
p.E391K	TCGA-W3-AA1V	SKCM	TCGA	FKENM	DEG_APCC_KENBOX_2	0.25
p.E391K	DO51276	SKCM	ICGC	FKENM	DEG_APCC_KENBOX_2	0.25
p.H382N	DO228971	LICA	ICGC	FKENM	DEG_APCC_KENBOX_2	0.2778
p.H382N	DO229038	LICA	ICGC	FKENM	DEG_APCC_KENBOX_2	0.2778
p.P377L	DO231628	LINC	ICGC	FKENM	DEG_APCC_KENBOX_2	0.1389
p.P376S	DO220899	MELA	ICGC	FKENM	DEG_APCC_KENBOX_2	0.1111
p.M388L	SIDM00177	Melanoma	GDSC	FKENM	DEG_APCC_KENBOX_2	0.5999
p.M388L	ACH-002338	Skin Cancer	CCLE	FKENM	DEG_APCC_KENBOX_2	0.5999
p.M388L	ACH-002510	Skin Cancer	CCLE	FKENM	DEG_APCC_KENBOX_2	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHJ3	Scm-like with four MBT domains protein 1	DEG_APCC_KENBOX_2	384:388	FKENM	APC,CDC20,FZR1	0.6089	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons