DegronMD

Uniprot ID: Q9UHJ3

Source protein: Scm-like with four MBT domains protein 1

Source gene: SFMBT1

Class: DEG_SCF_FBW7_1

Location: 686:693

E3 ligase: FBXW7

DEGRON score: 0.9037

ASA_SCORE: 67.4125

COIL: 0.8531

CONS_SCORE: 0.4568

DSS_SCORE: 0.83

HELIX: 0.043

FCONS_SCORE: 1.0238

RIG_SCORE: 0.5349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V676I	TCGA-96-8169	LUSC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	0.0556
p.V676I	DO26737	LUSC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.0556
p.R681C	TCGA-AP-A051	UCEC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.R681C	TCGA-AX-A2HC	UCEC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.R681C	DO41572	UCEC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.R681C	DO42673	UCEC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.R681C	SIDM00500	Colorectal Carcinoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.R681C	ACH-000959	Colon/Colorectal Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	0.1944
p.K678R	TCGA-BR-8680	STAD	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	0.2222
p.K678R	DO47769	STAD	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.2222
p.E702K	TCGA-IR-A3LL	CESC	TCGA	VDNTPAGS	DEG_SCF_FBW7_1	0.0833
p.E702K	DO44362	CESC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.0833
p.A691V	DO233766	GACA	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.5825
p.A691V	SIDM00910	Neuroblastoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	0.5825
p.A691V	ACH-000120	Neuroblastoma	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	0.5825
p.A691V	CHP-212	autonomic_ganglia	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	0.5825
p.A691E	DO228948	LICA	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.659
p.P690A	DO231179	LUSC	ICGC	VDNTPAGS	DEG_SCF_FBW7_1	0.7503
p.H677Y	SIDM00663	Melanoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	0.0833
p.H677Y	ACH-000814	Skin Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	0.0833
p.H677Y	Hs939-T	skin	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	0.0833
p.G692D	SIDM00217	Colorectal Carcinoma	GDSC	VDNTPAGS	DEG_SCF_FBW7_1	0.6087
p.G692D	ACH-000999	Colon/Colorectal Cancer	CCLE	VDNTPAGS	DEG_SCF_FBW7_1	0.6087
p.G692D	SNU-1040	large_intestine	COSMIC	VDNTPAGS	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHJ3	Scm-like with four MBT domains protein 1	DEG_SCF_FBW7_1	686:693	VDNTPAGS	FBXW7	0.9037	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons