DegronMD - Q01955(COL4A3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R791Q	TCGA-06-5416	GBM	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.R791Q	TCGA-14-1795	GBM	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.R791Q	TCGA-XF-A9SG	BLCA	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.R791Q	DO51912	BLCA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.R791Q	DO13114	GBM	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.R791Q	DO10880	GBM	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1667
p.G112D	TCGA-19-5956	GBM	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation altering degron motif	0.6087
p.G112D	DO13863	GBM	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation altering degron motif	0.6087
p.G622V	TCGA-3C-AALI	BRCA	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622V	DO219589	BRCA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.P556Q	TCGA-43-7656	LUSC	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1389
p.P556Q	DO26424	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1389
p.P580R	TCGA-56-8628	LUSC	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.0833
p.P580R	DO45433	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.0833
p.G768E	TCGA-61-1998	OV	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.0556
p.G768E	DO28813	OV	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.0556
p.Q627H	TCGA-75-6214	LUAD	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.0833
p.Q627H	DO24830	LUAD	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.0833
p.G97R	TCGA-86-8585	LUAD	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.0556
p.G97R	DO24850	LUAD	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.0556
p.L787F	TCGA-B5-A0JY	UCEC	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2778
p.L787F	DO43041	UCEC	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2778
p.G622R	TCGA-D3-A1Q6	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	TCGA-EE-A2MI	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	DO220877	MELA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	DO37531	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	DO37450	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	SIDM00007	Other Solid Cancers	GDSC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	ACH-001550	Skin Cancer	CCLE	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622R	MCC13	skin	COSMIC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	TCGA-D3-A1Q6	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	TCGA-DA-A1I4	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	TCGA-EE-A2MI	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	DO220872	MELA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	DO37655	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	DO37531	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G622E	DO37450	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.W1441L	TCGA-D3-A2JC	SKCM	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.3056
p.W1441L	DO229031	LICA	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.3056
p.W1441L	DO47578	SKCM	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.3056
p.G1430R	TCGA-D6-6516	HNSC	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.2222
p.G1430R	DO15623	HNSC	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.2222
p.G608E	TCGA-D9-A1JW	SKCM	TCGA	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1389
p.G608E	DO37786	SKCM	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1389
p.G1054R	TCGA-EB-A430	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1389
p.G1054R	DO220912	MELA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1389
p.G1054R	DO37906	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1389
p.G1054R	ACH-002508	Skin Cancer	CCLE	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1389
p.P1044Q	TCGA-EE-A181	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5924
p.P1044Q	DO37444	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5924
p.K1053N	TCGA-EE-A2MH	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation substituting flanking lysine	0.2778
p.K1053N	DO37539	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation substituting flanking lysine	0.2778
p.G1030E	TCGA-EE-A3AB	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.G1030E	DO222670	MELA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.G1030E	DO38057	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0833
p.G1051E	TCGA-FW-A3TV	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2222
p.G1051E	DO38159	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2222
p.R1029K	TCGA-HU-A4H8	STAD	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.R1029K	DO47869	STAD	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.G780V	TCGA-J7-6720	KIRP	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6421
p.G780V	DO20855	KIRP	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6421
p.P1438H	TCGA-VQ-A8PO	STAD	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation altering degron motif	0.6583
p.P1438H	DO51773	STAD	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation altering degron motif	0.6583
p.D568N	TCGA-XK-AAIW	PRAD	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.5821
p.D568N	DO51407	PRAD	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.5821
p.G100R	TCGA-Z2-A8RT	SKCM	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1389
p.G100R	DO51301	SKCM	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1389
p.G115V	DO224717	BRCA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.3056
p.P574L	DO227709	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.P574L	DO229010	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.P574L	DO229013	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.P574L	DO229016	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.P574L	DO52365	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.P556L	DO234394	ESAD	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1389
p.T573I	DO233780	GACA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.2778
p.G1051R	DO233705	GACA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2222
p.A610S	DO228976	LICA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1944
p.G566V	DO229029	LICA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6421
p.G619V	DO229028	LICA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.3056
p.G121C	DO229022	LICA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1389
p.R1037L	DO229031	LICA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2778
p.A613S	DO229035	LICA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2778
p.G560V	DO229037	LICA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.25
p.G789V	DO229008	LICA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2222
p.G100E	DO220894	MELA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1389
p.G783E	DO222396	MELA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6087
p.G783E	SIDM00007	Other Solid Cancers	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6087
p.G783E	ACH-001550	Skin Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6087
p.G783E	MCC13	skin	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.6087
p.G611E	DO222875	MELA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G611E	DO229459	SKCA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.2222
p.G1433R	DO222843	MELA	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.3056
p.G628S	DO222908	MELA	ICGC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.0556
p.G106E	DO229232	THCA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.3056
p.V1447A	SIDM00697	Small Cell Lung Carcinoma	GDSC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.1389
p.V1447A	ACH-000830	Lung Cancer	CCLE	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.1389
p.V1447A	NCI-H1436	lung	COSMIC	DSGSPAT	DEG_SCF_TRCP1_1	1434:1440	Mutation rewiring degron network	0.1389
p.L787P	SIDM00370	T-Lymphoblastic Leukemia	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2778
p.L787P	ACH-000197	Leukemia	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2778
p.L787P	TALL-1	haematopoietic and lymphoid tissue	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2778
p.P624A	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.P624A	ACH-000447	Lung Cancer	CCLE	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.P624A	NCI-H2228	lung	COSMIC	PPGY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.G789R	SIDM00221	Melanoma	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2222
p.G789R	ACH-002388	Skin Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.2222
p.R1029G	SIDM00498	Colorectal Carcinoma	GDSC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.R1029G	ACH-000970	Colon/Colorectal Cancer	CCLE	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.R1029G	SNU-C5	large intestine	COSMIC	GRPGLPGIH	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.0556
p.P779T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.5919
p.P779T	ACH-001127	Leukemia	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.5919
p.P779T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation altering degron motif	0.5919
p.F101S	SIDM01450	Gastric Carcinoma	GDSC	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1667
p.F101S	ACH-000898	Gastric Cancer	CCLE	LPGTPGNT	DEG_SCF_FBW7_1	107:114	Mutation rewiring degron network	0.1667
p.G628C	ACH-001377	Pancreatic Cancer	CCLE	PPGY	ITCH	615:618	Mutation rewiring degron network	0.0556
p.G771E	ACH-001415	Bladder Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	778:785	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A3

UniProt ID: Q01955

Entrez ID: 1285

Protein name: Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A3 in