DegronMD

Uniprot ID: Q01955

Source protein: Collagen alpha-3

Source gene: COL4A3

Class: DEG_SCF_FBW7_2

Location: 778:785

E3 ligase: FBXW7

DEGRON score: 0.9896

ASA_SCORE: 75.2625

COIL: 0.9436

CONS_SCORE: 0.5607

DSS_SCORE: 0.8495

HELIX: 0.0134

FCONS_SCORE: 1.0338

RIG_SCORE: 0.5177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R791Q	TCGA-06-5416	GBM	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.R791Q	TCGA-14-1795	GBM	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.R791Q	TCGA-XF-A9SG	BLCA	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.R791Q	DO51912	BLCA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.R791Q	DO13114	GBM	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.R791Q	DO10880	GBM	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.1667
p.G768E	TCGA-61-1998	OV	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.0556
p.G768E	DO28813	OV	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.0556
p.L787F	TCGA-B5-A0JY	UCEC	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.2778
p.L787F	DO43041	UCEC	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.2778
p.G780V	TCGA-J7-6720	KIRP	TCGA	LPGTPGNE	DEG_SCF_FBW7_2	0.6421
p.G780V	DO20855	KIRP	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.6421
p.G789V	DO229008	LICA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.2222
p.G783E	DO222396	MELA	ICGC	LPGTPGNE	DEG_SCF_FBW7_2	0.6087
p.G783E	SIDM00007	Other Solid Cancers	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	0.6087
p.G783E	ACH-001550	Skin Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	0.6087
p.G783E	MCC13	skin	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	0.6087
p.L787P	SIDM00370	T-Lymphoblastic Leukemia	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	0.2778
p.L787P	ACH-000197	Leukemia	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	0.2778
p.L787P	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	0.2778
p.G789R	SIDM00221	Melanoma	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	0.2222
p.G789R	ACH-002388	Skin Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	0.2222
p.P779T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LPGTPGNE	DEG_SCF_FBW7_2	0.5919
p.P779T	ACH-001127	Leukemia	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	0.5919
p.P779T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPGNE	DEG_SCF_FBW7_2	0.5919
p.G771E	ACH-001415	Bladder Cancer	CCLE	LPGTPGNE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01955	Collagen alpha-3	DEG_SCF_FBW7_2	778:785	LPGTPGNE	FBXW7	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPGTPGNE

Degron related mutations and impact score

Drug responses associated with COL4A3 mutations

All proteins holding degron of LPGTPGNE