DegronMD

Uniprot ID: Q01955

Source protein: Collagen alpha-3

Source gene: COL4A3

Class: DEG_APCC_DBOX_1

Location: 1039:1047

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9593

ASA_SCORE: 73.7111

COIL: 0.926

CONS_SCORE: 0.6012

DSS_SCORE: 0.7378

HELIX: 0.0086

FCONS_SCORE: 1.0062

RIG_SCORE: 0.6049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1054R	TCGA-EB-A430	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.1389
p.G1054R	DO220912	MELA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.1389
p.G1054R	DO37906	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.1389
p.G1054R	ACH-002508	Skin Cancer	CCLE	GRPGLPGIH	DEG_APCC_DBOX_1	0.1389
p.P1044Q	TCGA-EE-A181	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.5924
p.P1044Q	DO37444	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.5924
p.K1053N	TCGA-EE-A2MH	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.2778
p.K1053N	DO37539	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.2778
p.G1030E	TCGA-EE-A3AB	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.0833
p.G1030E	DO222670	MELA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.0833
p.G1030E	DO38057	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.0833
p.G1051E	TCGA-FW-A3TV	SKCM	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.2222
p.G1051E	DO38159	SKCM	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.2222
p.R1029K	TCGA-HU-A4H8	STAD	TCGA	GRPGLPGIH	DEG_APCC_DBOX_1	0.0556
p.R1029K	DO47869	STAD	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.0556
p.G1051R	DO233705	GACA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.2222
p.R1037L	DO229031	LICA	ICGC	GRPGLPGIH	DEG_APCC_DBOX_1	0.2778
p.R1029G	SIDM00498	Colorectal Carcinoma	GDSC	GRPGLPGIH	DEG_APCC_DBOX_1	0.0556
p.R1029G	ACH-000970	Colon/Colorectal Cancer	CCLE	GRPGLPGIH	DEG_APCC_DBOX_1	0.0556
p.R1029G	SNU-C5	large_intestine	COSMIC	GRPGLPGIH	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01955	Collagen alpha-3	DEG_APCC_DBOX_1	1039:1047	GRPGLPGIH	APC,CDC20,FZR1	0.9593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons