DegronMD

Uniprot ID: Q01955

Source protein: Collagen alpha-3

Source gene: COL4A3

Class: DEG_APCC_DBOX_1

Location: 563:571

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 75.7556

COIL: 0.9404

CONS_SCORE: 0.5359

DSS_SCORE: 0.771

HELIX: 0.0109

FCONS_SCORE: 0.9957

RIG_SCORE: 0.6036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P556Q	TCGA-43-7656	LUSC	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	0.1389
p.P556Q	DO26424	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.1389
p.P580R	TCGA-56-8628	LUSC	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	0.0833
p.P580R	DO45433	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.0833
p.D568N	TCGA-XK-AAIW	PRAD	TCGA	GRKGLDGIP	DEG_APCC_DBOX_1	0.5821
p.D568N	DO51407	PRAD	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.5821
p.P574L	DO227709	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25
p.P574L	DO229010	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25
p.P574L	DO229013	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25
p.P574L	DO229016	COCA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25
p.P574L	DO52365	LUSC	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25
p.P556L	DO234394	ESAD	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.1389
p.T573I	DO233780	GACA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.2778
p.G566V	DO229029	LICA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.6421
p.G560V	DO229037	LICA	ICGC	GRKGLDGIP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01955	Collagen alpha-3	DEG_APCC_DBOX_1	563:571	GRKGLDGIP	APC,CDC20,FZR1	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons