DegronMD

Uniprot ID: Q01955

Source protein: Collagen alpha-3

Source gene: COL4A3

Class: DEG_SCF_TRCP1_1

Location: 1434:1440

E3 ligase: BTRC

DEGRON score: 0.9916

ASA_SCORE: 63.1

COIL: 0.8881

CONS_SCORE: 0.5211

DSS_SCORE: 0.5829

HELIX: 0.0197

FCONS_SCORE: 0.8965

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W1441L	TCGA-D3-A2JC	SKCM	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	0.3056
p.W1441L	DO229031	LICA	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	0.3056
p.W1441L	DO47578	SKCM	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	0.3056
p.G1430R	TCGA-D6-6516	HNSC	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	0.2222
p.G1430R	DO15623	HNSC	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	0.2222
p.P1438H	TCGA-VQ-A8PO	STAD	TCGA	DSGSPAT	DEG_SCF_TRCP1_1	0.6583
p.P1438H	DO51773	STAD	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	0.6583
p.G1433R	DO222843	MELA	ICGC	DSGSPAT	DEG_SCF_TRCP1_1	0.3056
p.V1447A	SIDM00697	Small Cell Lung Carcinoma	GDSC	DSGSPAT	DEG_SCF_TRCP1_1	0.1389
p.V1447A	ACH-000830	Lung Cancer	CCLE	DSGSPAT	DEG_SCF_TRCP1_1	0.1389
p.V1447A	NCI-H1436	lung	COSMIC	DSGSPAT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01955	Collagen alpha-3	DEG_SCF_TRCP1_1	1434:1440	DSGSPAT	BTRC	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons