DegronMD

Uniprot ID: Q01955

Source protein: Collagen alpha-3

Source gene: COL4A3

Class: DEG_SCF_FBW7_1

Location: 107:114

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 71.3

COIL: 0.9334

CONS_SCORE: 0.5553

DSS_SCORE: 0.5513

HELIX: 0.0116

FCONS_SCORE: 0.9034

RIG_SCORE: 0.5716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G112D	TCGA-19-5956	GBM	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	0.6087
p.G112D	DO13863	GBM	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.6087
p.G97R	TCGA-86-8585	LUAD	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	0.0556
p.G97R	DO24850	LUAD	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.0556
p.G100R	TCGA-Z2-A8RT	SKCM	TCGA	LPGTPGNT	DEG_SCF_FBW7_1	0.1389
p.G100R	DO51301	SKCM	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.1389
p.G115V	DO224717	BRCA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.3056
p.G121C	DO229022	LICA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.1389
p.G100E	DO220894	MELA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.1389
p.G106E	DO229232	THCA	ICGC	LPGTPGNT	DEG_SCF_FBW7_1	0.3056
p.F101S	SIDM01450	Gastric Carcinoma	GDSC	LPGTPGNT	DEG_SCF_FBW7_1	0.1667
p.F101S	ACH-000898	Gastric Cancer	CCLE	LPGTPGNT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01955	Collagen alpha-3	DEG_SCF_FBW7_1	107:114	LPGTPGNT	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons