DegronMD - Q14050(COL9A3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R231W	TCGA-2W-A8YY	CESC	TCGA	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.8634
p.R231W	DO223732	CESC	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.8634
p.R231W	DO233805	GACA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.8634
p.R583C	TCGA-3N-A9WC	SKCM	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583C	TCGA-EY-A1GI	UCEC	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583C	DO224801	COCA	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583C	DO51234	SKCM	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583C	DO41211	UCEC	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.D591E	TCGA-49-AARN	LUAD	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.D591E	DO218923	LUAD	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.R577Q	TCGA-75-5126	LUAD	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.R577Q	DO23711	LUAD	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.R577Q	SIDM01162	Kidney Carcinoma	GDSC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.R577Q	SW156	kidney	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.R231Q	TCGA-A5-A0VP	UCEC	TCGA	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.7329
p.R231Q	DO42600	UCEC	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.7329
p.D591N	TCGA-BS-A0UF	UCEC	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.D591N	DO41488	UCEC	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.D591N	SIDM00963	Breast Carcinoma	GDSC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.D591N	ACH-000927	Breast Cancer	CCLE	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.D591N	BT-474	breast	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.G581R	TCGA-CQ-A4CE	HNSC	TCGA	PPGY	ITCH	579:582	Mutation altering degron motif	0.6457
p.G581R	DO49071	HNSC	ICGC	PPGY	ITCH	579:582	Mutation altering degron motif	0.6457
p.G578R	TCGA-CV-7568	HNSC	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.G578R	DO14160	HNSC	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.G578E	TCGA-CV-7568	HNSC	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.G578E	DO14160	HNSC	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.G584C	TCGA-D3-A2JL	SKCM	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584C	DO229041	LICA	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584C	DO47278	SKCM	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.S570F	TCGA-DA-A3F8	SKCM	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.S570F	DO37418	SKCM	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.G584S	TCGA-EO-A22U	UCEC	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584S	TCGA-R5-A7ZI	STAD	TCGA	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584S	DO222769	COCA	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584S	DO222342	STAD	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.G584S	DO43755	UCEC	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2778
p.P242H	DO234253	ESAD	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.1111
p.G581E	DO49661	LIAD	ICGC	PPGY	ITCH	579:582	Mutation altering degron motif	0.6087
p.G223V	DO228978	LICA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.2222
p.G217W	DO228986	LICA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.0556
p.G223S	DO220859	MELA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.2222
p.S570A	DO222402	MELA	ICGC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.0833
p.G232R	DO219871	SKCA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.7568
p.G241W	DO229248	THCA	ICGC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.1389
p.G241R	SIDM01302	Esophageal Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.1389
p.G241R	SIDM00487	Colorectal Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.1389
p.G241R	ACH-000963	Colon/Colorectal Cancer	CCLE	LQGPRGLR	SCF_FBXL2	227:234	Mutation rewiring degron network	0.1389
p.R583H	SIDM00453	Pancreatic Carcinoma	GDSC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583H	SIDM00779	Colorectal Carcinoma	GDSC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583H	SIDM01146	Gastric Carcinoma	GDSC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583H	PA-TU-8988T	pancreas	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583H	NCI-SNU-1	stomach	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R583H	NCI-H716	large intestine	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.3056
p.R234P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	227:234	Mutation altering degron motif	0.7512
p.T586P	PANC-03-27	pancreas	COSMIC	PPGY	ITCH	579:582	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL9A3

UniProt ID: Q14050

Entrez ID: 1299

Protein name: Collagen alpha-3(IX) chain

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL9A3 in