DegronMD

Uniprot ID: Q14050

Source protein: Collagen alpha-3

Source gene: COL9A3

Class: SCF_FBXL2

Location: 227:234

E3 ligase: FBXL2

DEGRON score: 0.6359

ASA_SCORE: 90.225

COIL: 0.9334

CONS_SCORE: 0.7935

DSS_SCORE: 0.7294

HELIX: 0.0212

FCONS_SCORE: 1.0213

RIG_SCORE: 0.6092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R231W	TCGA-2W-A8YY	CESC	TCGA	LQGPRGLR	SCF_FBXL2	0.8634
p.R231W	DO223732	CESC	ICGC	LQGPRGLR	SCF_FBXL2	0.8634
p.R231W	DO233805	GACA	ICGC	LQGPRGLR	SCF_FBXL2	0.8634
p.R231Q	TCGA-A5-A0VP	UCEC	TCGA	LQGPRGLR	SCF_FBXL2	0.7329
p.R231Q	DO42600	UCEC	ICGC	LQGPRGLR	SCF_FBXL2	0.7329
p.P242H	DO234253	ESAD	ICGC	LQGPRGLR	SCF_FBXL2	0.1111
p.G223V	DO228978	LICA	ICGC	LQGPRGLR	SCF_FBXL2	0.2222
p.G217W	DO228986	LICA	ICGC	LQGPRGLR	SCF_FBXL2	0.0556
p.G223S	DO220859	MELA	ICGC	LQGPRGLR	SCF_FBXL2	0.2222
p.G232R	DO219871	SKCA	ICGC	LQGPRGLR	SCF_FBXL2	0.7568
p.G241W	DO229248	THCA	ICGC	LQGPRGLR	SCF_FBXL2	0.1389
p.G241R	SIDM01302	Esophageal Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	0.1389
p.G241R	SIDM00487	Colorectal Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	0.1389
p.G241R	ACH-000963	Colon/Colorectal Cancer	CCLE	LQGPRGLR	SCF_FBXL2	0.1389
p.R234P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LQGPRGLR	SCF_FBXL2	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14050	Collagen alpha-3	SCF_FBXL2	227:234	LQGPRGLR	FBXL2	0.6359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons