DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPGY
Uniprot ID:
Q5JSL3
Source protein:
Dedicator of cytokinesis protein 11
Source gene:
DOCK11
Class:
ITCH
Location:
782:785
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.5608
ASA_SCORE:
53.875
COIL:
0.7928
CONS_SCORE:
0.6294
DSS_SCORE:
0.3016
HELIX:
0.1283
FCONS_SCORE:
1.4429
RIG_SCORE:
0.75
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P783S
TCGA-EE-A3AG
SKCM
TCGA
PPGY
ITCH
0.6752
p.P783S
DO37471
SKCM
ICGC
PPGY
ITCH
0.6752
p.P783S
SIDM00539
Esophageal Carcinoma
GDSC
PPGY
ITCH
0.6752
p.D790N
TCGA-JW-A5VL
CESC
TCGA
PPGY
ITCH
0.1944
p.D790N
DO49976
CESC
ICGC
PPGY
ITCH
0.1944
p.S793L
TCGA-34-5927
LUSC
TCGA
PPGY
ITCH
0.1111
p.S793L
DO27731
LUSC
ICGC
PPGY
ITCH
0.1111
p.S793L
SIDM00381
Cervical Carcinoma
GDSC
PPGY
ITCH
0.1111
p.S793L
SKG-IIIa
cervix
COSMIC
PPGY
ITCH
0.1111
Showing 1 to 9 of 9 entries
Previous
1
Next
Drug responses associated with DOCK11 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PPGY
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95622
Adenylate cyclase type 5
ITCH
9:12
PPGY
ITCH,NEDD4
0.9301
More...
Q9BTX7
Alpha-tocopherol transfer protein-like
ITCH
28:31
PPGY
ITCH,NEDD4
0.9959
More...
O14497
AT-rich interactive domain-containing protein 1A
ITCH
912:915
PPGY
ITCH,NEDD4
0.9986
More...
P54259
Atrophin-1
ITCH
654:657
PPGY
ITCH,NEDD4
0.9979
More...
P54259
Atrophin-1
ITCH
670:673
PPGY
ITCH,NEDD4
0.9978
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
1088:1091
PPGY
ITCH,NEDD4
0.9811
More...
P98160
Basement membrane-specific heparan sulfate proteoglycan core protein
ITCH
1129:1132
PPGY
ITCH,NEDD4
0.621
More...
P11274
Breakpoint cluster region protein
ITCH
433:436
PPGY
ITCH,NEDD4
0.9994
More...
P27708
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase
ITCH
1802:1805
PPGY
ITCH,NEDD4
0.9935
More...
Q9H078
Caseinolytic peptidase B protein homolog
ITCH
427:430
PPGY
ITCH,NEDD4
0.978
More...
P49715
CCAAT/enhancer-binding protein alpha
ITCH
128:131
PPGY
ITCH,NEDD4
0.7286
More...
Q7Z7A1
Centriolin
ITCH
1241:1244
PPGY
ITCH,NEDD4
0.5834
More...
Q12873
Chromodomain-helicase-DNA-binding protein 3
ITCH
1928:1931
PPGY
ITCH,NEDD4
0.7534
More...
P02462
Collagen alpha-1
ITCH
605:608
PPGY
ITCH,NEDD4
0.6191
More...
Q07092
Collagen alpha-1
ITCH
1542:1545
PPGY
ITCH,NEDD4
0.9879
More...
Q2UY09
Collagen alpha-1
ITCH
703:706
PPGY
ITCH,NEDD4
0.9911
More...
Q99715
Collagen alpha-1
ITCH
3040:3043
PPGY
ITCH,NEDD4
0.9593
More...
Q14055
Collagen alpha-2
ITCH
563:566
PPGY
ITCH,NEDD4
0.9513
More...
P25940
Collagen alpha-3
ITCH
705:708
PPGY
ITCH,NEDD4
0.9233
More...
Q01955
Collagen alpha-3
ITCH
615:618
PPGY
ITCH,NEDD4
0.605
More...
Q14050
Collagen alpha-3
ITCH
579:582
PPGY
ITCH,NEDD4
0.7798
More...
P53420
Collagen alpha-4
ITCH
1308:1311
PPGY
ITCH,NEDD4
0.6498
More...
Q5VXM1
CUB domain-containing protein 2
ITCH
290:293
PPGY
ITCH,NEDD4
0.707
More...
Q5JSL3
Dedicator of cytokinesis protein 11
ITCH
782:785
PPGY
ITCH,NEDD4
0.5608
More...
Q92796
Disks large homolog 3
ITCH
27:30
PPGY
ITCH,NEDD4
0.8861
More...
Showing 1 to 25 of 106 entries
Previous
1
2
3
4
5
Next
