DegronMD - Q14055(COL9A2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K569N	TCGA-77-8154	LUSC	TCGA	PPGY	ITCH	563:566	Mutation substituting flanking lysine	0.3611
p.K569N	DO27224	LUSC	ICGC	PPGY	ITCH	563:566	Mutation substituting flanking lysine	0.3611
p.E535K	TCGA-98-7454	LUSC	TCGA	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.E535K	DO26460	LUSC	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.A551V	TCGA-AA-3510	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.5825
p.A551V	DO7783	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.5825
p.R546Q	TCGA-AY-5543	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.7329
p.R546Q	DO9748	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.7329
p.R546W	TCGA-CM-4746	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.8634
p.R546W	DO7882	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.8634
p.P557L	TCGA-FW-A3R5	SKCM	TCGA	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.2222
p.P557L	TCGA-FW-A3R5	SKCM	TCGA	PPGY	ITCH	563:566	Mutation rewiring degron network	0.1667
p.P557L	DO37406	SKCM	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.2222
p.P557L	DO37406	SKCM	ICGC	PPGY	ITCH	563:566	Mutation rewiring degron network	0.1667
p.P567T	DO230326	COCA	ICGC	PPGY	ITCH	563:566	Mutation rewiring degron network	0.3056
p.G553D	DO23410	LINC	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.6087
p.A541S	DO229224	THCA	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.2222
p.M555L	DO229234	THCA	ICGC	KREALGAVG	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.2778
p.M555L	DO229234	THCA	ICGC	PPGY	ITCH	563:566	Mutation rewiring degron network	0.1111
p.P567L	ACH-000873	Esophageal Cancer	CCLE	PPGY	ITCH	563:566	Mutation rewiring degron network	0.3056

Kaplan plot for COL9A2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL9A2

UniProt ID: Q14055

Entrez ID: 1298

Protein name: Collagen alpha-2(IX) chain

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL9A2 in