DegronMD

Uniprot ID: Q14055

Source protein: Collagen alpha-2

Source gene: COL9A2

Class: DEG_APCC_DBOX_1

Location: 545:553

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8946

ASA_SCORE: 81.1889

COIL: 0.8909

CONS_SCORE: 0.845

DSS_SCORE: 0.4461

HELIX: 0.0656

FCONS_SCORE: 0.9261

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E535K	TCGA-98-7454	LUSC	TCGA	KREALGAVG	DEG_APCC_DBOX_1	0.0556
p.E535K	DO26460	LUSC	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.0556
p.A551V	TCGA-AA-3510	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	0.5825
p.A551V	DO7783	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.5825
p.R546Q	TCGA-AY-5543	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	0.7329
p.R546Q	DO9748	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.7329
p.R546W	TCGA-CM-4746	COAD	TCGA	KREALGAVG	DEG_APCC_DBOX_1	0.8634
p.R546W	DO7882	COAD	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.8634
p.P557L	TCGA-FW-A3R5	SKCM	TCGA	KREALGAVG	DEG_APCC_DBOX_1	0.2222
p.P557L	DO37406	SKCM	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.2222
p.G553D	DO23410	LINC	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.6087
p.A541S	DO229224	THCA	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.2222
p.M555L	DO229234	THCA	ICGC	KREALGAVG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14055	Collagen alpha-2	DEG_APCC_DBOX_1	545:553	KREALGAVG	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons