DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: ITCH

Location: 970:973

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9351

ASA_SCORE: 91.575

COIL: 0.9798

CONS_SCORE: 0.7793

DSS_SCORE: 0.8117

HELIX: 0.0075

FCONS_SCORE: 1.2667

RIG_SCORE: 0.5172

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G972C	TCGA-G4-6302	COAD	TCGA	PPGY	ITCH	0.6489
p.G972C	DO8778	COAD	ICGC	PPGY	ITCH	0.6489
p.P982S	DO10324	COAD	ICGC	PPGY	ITCH	0.0833
p.P982T	DO228978	LICA	ICGC	PPGY	ITCH	0.0833
p.P982T	DO229018	LICA	ICGC	PPGY	ITCH	0.0833
p.P970R	DO23102	LINC	ICGC	PPGY	ITCH	0.7512
p.P974S	DO220852	MELA	ICGC	PPGY	ITCH	0.3056
p.R969Q	SIDM00583	Pancreatic Carcinoma	GDSC	PPGY	ITCH	0.3056
p.R969Q	KP-1N	pancreas	COSMIC	PPGY	ITCH	0.3056
p.R981S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	PPGY	ITCH	0.1111
p.R981M	ACH-000936	Ovarian Cancer	CCLE	PPGY	ITCH	0.1111

Drug responses associated with NCOA6 mutations

All proteins holding degron of PPGY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B1AK53	Espin	ITCH	452:455	PPGY	ITCH,NEDD4	0.988	More...
O00712	Nuclear factor 1 B-type	ITCH	204:207	PPGY	ITCH,NEDD4	0.991	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	912:915	PPGY	ITCH,NEDD4	0.9986	More...
O14782	Kinesin-like protein KIF3C	ITCH	418:421	PPGY	ITCH,NEDD4	0.9179	More...
O15040	Tectonin beta-propeller repeat-containing protein 2	ITCH	1372:1375	PPGY	ITCH,NEDD4	0.9904	More...
O15162	Phospholipid scramblase 1	ITCH	33:36	PPGY	ITCH,NEDD4	0.9915	More...
O43451	Maltase-glucoamylase	ITCH	1159:1162	PPGY	ITCH,NEDD4	0.795	More...
O43451	Maltase-glucoamylase	ITCH	2055:2058	PPGY	ITCH,NEDD4	0.5074	More...
O60291	E3 ubiquitin-protein ligase MGRN1	ITCH	383:386	PPGY	ITCH,NEDD4	0.9865	More...
O95171	Sciellin	ITCH	168:171	PPGY	ITCH,NEDD4	0.8204	More...
O95486	Protein transport protein Sec24A	ITCH	296:299	PPGY	ITCH,NEDD4	0.9932	More...
O95622	Adenylate cyclase type 5	ITCH	9:12	PPGY	ITCH,NEDD4	0.9301	More...
O95967	EGF-containing fibulin-like extracellular matrix protein 2	ITCH	110:113	PPGY	ITCH,NEDD4	0.8013	More...
P02462	Collagen alpha-1	ITCH	605:608	PPGY	ITCH,NEDD4	0.6191	More...
P11274	Breakpoint cluster region protein	ITCH	433:436	PPGY	ITCH,NEDD4	0.9994	More...
P15173	Myogenin	ITCH	32:35	PPGY	ITCH,NEDD4	0.9806	More...
P17302	Gap junction alpha-1 protein	ITCH	283:286	PPGY	ITCH,NEDD4	0.9975	More...
P19484	Transcription factor EB	ITCH	410:413	PPGY	ITCH,NEDD4	0.9681	More...
P25940	Collagen alpha-3	ITCH	705:708	PPGY	ITCH,NEDD4	0.9233	More...
P27708	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	ITCH	1802:1805	PPGY	ITCH,NEDD4	0.9935	More...
P35713	Transcription factor SOX-18	ITCH	5:8	PPGY	ITCH,NEDD4	0.9979	More...
P36383	Gap junction gamma-1 protein	ITCH	287:290	PPGY	ITCH,NEDD4	0.8116	More...
P49715	CCAAT/enhancer-binding protein alpha	ITCH	128:131	PPGY	ITCH,NEDD4	0.7286	More...
P53420	Collagen alpha-4	ITCH	1308:1311	PPGY	ITCH,NEDD4	0.6498	More...
P54259	Atrophin-1	ITCH	654:657	PPGY	ITCH,NEDD4	0.9979	More...
P54259	Atrophin-1	ITCH	670:673	PPGY	ITCH,NEDD4	0.9978	More...
P84022	Mothers against decapentaplegic homolog 3	ITCH	181:184	PPGY	ITCH,NEDD4	0.9859	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1129:1132	PPGY	ITCH,NEDD4	0.621	More...
Q01955	Collagen alpha-3	ITCH	615:618	PPGY	ITCH,NEDD4	0.605	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	ITCH	825:828	PPGY	ITCH,NEDD4	0.9883	More...
Q07092	Collagen alpha-1	ITCH	1542:1545	PPGY	ITCH,NEDD4	0.9879	More...
Q12873	Chromodomain-helicase-DNA-binding protein 3	ITCH	1928:1931	PPGY	ITCH,NEDD4	0.7534	More...
Q12965	Unconventional myosin-Ie	ITCH	958:961	PPGY	ITCH,NEDD4	0.9853	More...
Q14050	Collagen alpha-3	ITCH	579:582	PPGY	ITCH,NEDD4	0.7798	More...
Q14055	Collagen alpha-2	ITCH	563:566	PPGY	ITCH,NEDD4	0.9513	More...
Q14157	Ubiquitin-associated protein 2-like	ITCH	903:906	PPGY	ITCH,NEDD4	0.9234	More...
Q14296	Fas-activated serine/threonine kinase	ITCH	425:428	PPGY	ITCH,NEDD4	0.8937	More...
Q14517	Protocadherin Fat 1	ITCH	4520:4523	PPGY	ITCH,NEDD4	0.9959	More...
Q14686	Nuclear receptor coactivator 6	ITCH	970:973	PPGY	ITCH,NEDD4	0.9351	More...
Q14694	Ubiquitin carboxyl-terminal hydrolase 10	ITCH	156:159	PPGY	ITCH,NEDD4	0.9968	More...
Q14CZ8	Hepatocyte cell adhesion molecule	ITCH	337:340	PPGY	ITCH,NEDD4	0.9992	More...
Q15149	Plectin	ITCH	495:498	PPGY	ITCH,NEDD4	0.7933	More...
Q15796	Mothers against decapentaplegic homolog 2	ITCH	222:225	PPGY	ITCH,NEDD4	0.9971	More...
Q2UY09	Collagen alpha-1	ITCH	703:706	PPGY	ITCH,NEDD4	0.9911	More...
Q3KP66	Innate immunity activator protein	ITCH	513:516	PPGY	ITCH,NEDD4	0.9461	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	ITCH	82:85	PPGY	ITCH,NEDD4	0.995	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	ITCH	838:841	PPGY	ITCH,NEDD4	0.9981	More...
Q5T6F2	Ubiquitin-associated protein 2	ITCH	907:910	PPGY	ITCH,NEDD4	0.9054	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	ITCH	528:531	PPGY	ITCH,NEDD4	0.9988	More...
Q6ZRS2	Helicase SRCAP	ITCH	1134:1137	PPGY	ITCH,NEDD4	0.9097	More...
Q7Z7A1	Centriolin	ITCH	1241:1244	PPGY	ITCH,NEDD4	0.5834	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	ITCH	136:139	PPGY	ITCH,NEDD4	0.9382	More...
Q7Z7L1	Schlafen family member 11	ITCH	401:404	PPGY	ITCH,NEDD4	0.5536	More...
Q86Y91	Kinesin-like protein KIF18B	ITCH	585:588	PPGY	ITCH,NEDD4	0.9982	More...
Q8IUW3	Spermatogenesis-associated protein 2-like protein	ITCH	352:355	PPGY	ITCH,NEDD4	0.6915	More...
Q8IYX7	Stabilizer of axonemal microtubules 1	ITCH	427:430	PPGY	ITCH,NEDD4	0.9804	More...
Q8N196	Homeobox protein SIX5	ITCH	459:462	PPGY	ITCH,NEDD4	0.9895	More...
Q8TAB3	Protocadherin-19	ITCH	363:366	PPGY	ITCH,NEDD4	0.5027	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	ITCH	1508:1511	PPGY	ITCH,NEDD4	0.9985	More...
Q92530	Proteasome inhibitor PI31 subunit	ITCH	263:266	PPGY	ITCH,NEDD4	0.9986	More...
Q92796	Disks large homolog 3	ITCH	27:30	PPGY	ITCH,NEDD4	0.8861	More...
Q92900	Regulator of nonsense transcripts 1	ITCH	1005:1008	PPGY	ITCH,NEDD4	0.9291	More...
Q969V6	Myocardin-related transcription factor A	ITCH	725:728	PPGY	ITCH,NEDD4	0.9896	More...
Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ITCH	78:81	PPGY	ITCH,NEDD4	0.9951	More...
Q96PX1	E3 ubiquitin ligase RNF157	ITCH	361:364	PPGY	ITCH,NEDD4	0.9696	More...
Q96QT4	Transient receptor potential cation channel subfamily M member 7	ITCH	502:505	PPGY	ITCH,NEDD4	0.5359	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	187:190	PPGY	ITCH,NEDD4	0.8551	More...
Q99715	Collagen alpha-1	ITCH	3040:3043	PPGY	ITCH,NEDD4	0.9593	More...
Q99759	Mitogen-activated protein kinase kinase kinase 3	ITCH	178:181	PPGY	ITCH,NEDD4	0.9993	More...
Q9BRQ0	Pygopus homolog 2	ITCH	115:118	PPGY	ITCH,NEDD4	0.9929	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	ITCH	2168:2171	PPGY	ITCH,NEDD4	0.9731	More...
Q9H078	Caseinolytic peptidase B protein homolog	ITCH	427:430	PPGY	ITCH,NEDD4	0.978	More...
Q9H2D6	TRIO and F-actin-binding protein	ITCH	2102:2105	PPGY	ITCH,NEDD4	0.9697	More...
Q9H313	Protein tweety homolog 1	ITCH	4:7	PPGY	ITCH,NEDD4	0.6434	More...
Q9H5N1	Rab GTPase-binding effector protein 2	ITCH	281:284	PPGY	ITCH,NEDD4	0.8333	More...
Q9NRM1	Enamelin	ITCH	182:185	PPGY	ITCH,NEDD4	0.9502	More...
Q9NRR4	Ribonuclease 3	ITCH	169:172	PPGY	ITCH,NEDD4	0.9968	More...
Q9UHJ3	Scm-like with four MBT domains protein 1	ITCH	348:351	PPGY	ITCH,NEDD4	0.6016	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	ITCH	524:527	PPGY	ITCH,NEDD4	0.6223	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	ITCH	846:849	PPGY	ITCH,NEDD4	0.9903	More...
Q9UPW0	Forkhead box protein J3	ITCH	566:569	PPGY	ITCH,NEDD4	0.9959	More...
Q9UPY3	Endoribonuclease Dicer	ITCH	1382:1385	PPGY	ITCH,NEDD4	0.6827	More...
Q9Y2G1	Myelin regulatory factor	ITCH	92:95	PPGY	ITCH,NEDD4	0.9908	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	78:81	PPGY	ITCH,NEDD4	0.9937	More...
Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	ITCH	166:169	PPGY	ITCH,NEDD4	0.9985	More...
Q9Y4B5	Microtubule cross-linking factor 1	ITCH	1840:1843	PPGY	ITCH,NEDD4	0.9976	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	ITCH	1403:1406	PPGY	ITCH,NEDD4	0.9738	More...
Q9Y6C2	EMILIN-1	ITCH	397:400	PPGY	ITCH,NEDD4	0.9365	More...
Q9Y6X2	E3 SUMO-protein ligase PIAS3	ITCH	420:423	PPGY	ITCH,NEDD4	0.9902	More...
P36915	Guanine nucleotide-binding protein-like 1	ITCH	520:523	PPGY	ITCH,NEDD4	0.8237	More...
Q5JSL3	Dedicator of cytokinesis protein 11	ITCH	782:785	PPGY	ITCH,NEDD4	0.5608	More...
Q8IX06	Putative exonuclease GOR	ITCH	11:14	PPGY	ITCH,NEDD4	0.9962	More...
Q8IX06	Putative exonuclease GOR	ITCH	103:106	PPGY	ITCH,NEDD4	0.9941	More...
Q96MA1	Doublesex- and mab-3-related transcription factor B1	ITCH	285:288	PPGY	ITCH,NEDD4	0.533	More...
Q9Y5P3	Retinoic acid-induced protein 2	ITCH	206:209	PPGY	ITCH,NEDD4	0.8504	More...
O15442	Metallophosphoesterase domain-containing protein 1	ITCH	86:89	PPGY	ITCH,NEDD4	0.9478	More...
Q3B7T3	Protein BEAN1	ITCH	145:148	PPGY	ITCH,NEDD4	0.8583	More...
Q6BEB4	Transcription factor Sp5	ITCH	156:159	PPGY	ITCH,NEDD4	0.9859	More...
Q8IZJ4	Ral-GDS-related protein	ITCH	164:167	PPGY	ITCH,NEDD4	0.9828	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	1088:1091	PPGY	ITCH,NEDD4	0.9811	More...
A6NMB9	Fidgetin-like protein 2	ITCH	193:196	PPGY	ITCH,NEDD4	0.6371	More...
B6SEH8	Endogenous retrovirus group V member 1 Env polyprotein	ITCH	251:254	PPGY	ITCH,NEDD4	0.7435	More...
Q5T089	MORN repeat-containing protein 1	ITCH	376:379	PPGY	ITCH,NEDD4	0.9041	More...
Q5VXM1	CUB domain-containing protein 2	ITCH	290:293	PPGY	ITCH,NEDD4	0.707	More...
Q6ZQN5	Forkhead box protein I2	ITCH	24:27	PPGY	ITCH,NEDD4	0.9312	More...
Q9BTX7	Alpha-tocopherol transfer protein-like	ITCH	28:31	PPGY	ITCH,NEDD4	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGY

Degron related mutations and impact score

Drug responses associated with NCOA6 mutations

All proteins holding degron of PPGY