DegronMD - Q92530(PSMF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W146L	TCGA-80-5608	LUAD	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	TCGA-EE-A20F	SKCM	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO228986	LICA	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO23693	LUAD	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO37961	SKCM	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.S153I	TCGA-AF-2693	READ	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.5278
p.S153I	DO36766	READ	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.5278
p.D267N	TCGA-AX-A05Z	UCEC	TCGA	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.D267N	DO40884	UCEC	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.E129K	TCGA-AX-A1CJ	UCEC	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.0833
p.E129K	DO40828	UCEC	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.0833
p.M269I	TCGA-CD-8529	STAD	TCGA	PPGY	ITCH	263:266	Mutation rewiring degron network	0.25
p.M269I	DO47753	STAD	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.25
p.R133C	TCGA-D1-A103	UCEC	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133C	TCGA-DX-A8BP	SARC	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133C	DO233154	GACA	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133C	DO220056	SARC	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133C	DO42312	UCEC	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.P154L	TCGA-DG-A2KK	CESC	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.0556
p.P154L	DO51595	CESC	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.0556
p.N150S	TCGA-EO-A22X	UCEC	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1667
p.N150S	DO43907	UCEC	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1667
p.H260P	TCGA-UB-A7MA	LIHC	TCGA	PPGY	ITCH	263:266	Mutation rewiring degron network	0.25
p.H260P	DO52317	LIHC	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.25
p.P264L	DO222501	COCA	ICGC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7582
p.P253L	DO50309	ESAD	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.0556
p.R131L	DO229019	LICA	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1389
p.G255R	DO35083	PACA	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.1111
p.G255R	SIDM00539	Esophageal Carcinoma	GDSC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.1111
p.R133H	SIDM00741	Small Cell Lung Carcinoma	GDSC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133H	SIDM00251	Gastric Carcinoma	GDSC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133H	TGBC11TKB	stomach	COSMIC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.R133H	NCI-H1694	lung	COSMIC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.1944
p.P263A	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.P263A	ACH-000353	Esophageal Cancer	CCLE	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.P263A	TE-15	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.S136P	SIDM00534	Colorectal Carcinoma	GDSC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.S136P	ACH-000986	Colon/Colorectal Cancer	CCLE	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.S136P	HT-115	large intestine	COSMIC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.G262R	KYSE-150	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.G262R	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.G262R	TE-8	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056

Kaplan plot for PSMF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSMF1

UniProt ID: Q92530

Entrez ID: 9491

Protein name: Proteasome inhibitor PI31 subunit (hPI31)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSMF1 in