DegronMD - Q92530(PSMF1)

FUNCTION: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}.

GO - Biological processes (BP): negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]

GO - Molecular function (MF): endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]

GO - Cellular component (CC): cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
IITPIHE	DEG_SCF_FBW7_2	FBXW7	Proteasome inhibitor PI31 subunit	138:144	More..
PPGY	ITCH	ITCH,NEDD4	Proteasome inhibitor PI31 subunit	263:266	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P264L	DO222501	COCA	ICGC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7582
p.P263A	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.P263A	ACH-000353	Esophageal Cancer	CCLE	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.P263A	TE-15	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation altering degron motif	0.7503
p.S136P	SIDM00534	Colorectal Carcinoma	GDSC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.S136P	ACH-000986	Colon/Colorectal Cancer	CCLE	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.S136P	HT-115	large intestine	COSMIC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.7222
p.S153I	TCGA-AF-2693	READ	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.5278
p.S153I	DO36766	READ	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation blocking phosphorylation signal	0.5278
p.D267N	TCGA-AX-A05Z	UCEC	TCGA	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.D267N	DO40884	UCEC	ICGC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.G262R	KYSE-150	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.G262R	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.G262R	TE-8	oesophagus	COSMIC	PPGY	ITCH	263:266	Mutation rewiring degron network	0.3056
p.W146L	TCGA-80-5608	LUAD	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	TCGA-EE-A20F	SKCM	TCGA	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO228986	LICA	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO23693	LUAD	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.W146L	DO37961	SKCM	ICGC	IITPIHE	DEG_SCF_FBW7_2	138:144	Mutation rewiring degron network	0.2778
p.M269I	TCGA-CD-8529	STAD	TCGA	PPGY	ITCH	263:266	Mutation rewiring degron network	0.25

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No resistance data available for this Degron.

Kaplan plot for PSMF1 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSMF1

UniProt ID: Q92530

Entrez ID: 9491

Protein name: Proteasome inhibitor PI31 subunit (hPI31)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for PSMF1 in