DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IITPIHE
Uniprot ID:
Q92530
Source protein:
Proteasome inhibitor PI31 subunit
Source gene:
PSMF1
Class:
DEG_SCF_FBW7_2
Location:
138:144
E3 ligase:
FBXW7
DEGRON score:
0.9936
ASA_SCORE:
63.9857
COIL:
0.7561
CONS_SCORE:
0.4327
DSS_SCORE:
0.3379
HELIX:
0.1789
FCONS_SCORE:
1.133
RIG_SCORE:
0.7656
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W146L
TCGA-80-5608
LUAD
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
TCGA-EE-A20F
SKCM
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO228986
LICA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO23693
LUAD
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO37961
SKCM
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.S153I
TCGA-AF-2693
READ
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.5278
p.S153I
DO36766
READ
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.5278
p.E129K
TCGA-AX-A1CJ
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.0833
p.E129K
DO40828
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.0833
p.R133C
TCGA-D1-A103
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
TCGA-DX-A8BP
SARC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO233154
GACA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO220056
SARC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO42312
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.P154L
TCGA-DG-A2KK
CESC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.0556
p.P154L
DO51595
CESC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.0556
p.N150S
TCGA-EO-A22X
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1667
p.N150S
DO43907
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1667
p.R131L
DO229019
LICA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1389
p.R133H
SIDM00741
Small Cell Lung Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
SIDM00251
Gastric Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
TGBC11TKB
stomach
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
NCI-H1694
lung
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.S136P
SIDM00534
Colorectal Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.7222
p.S136P
ACH-000986
Colon/Colorectal Cancer
CCLE
IITPIHE
DEG_SCF_FBW7_2
0.7222
p.S136P
HT-115
large_intestine
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.7222
Drug responses associated with PSMF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IITPIHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92530
Proteasome inhibitor PI31 subunit
DEG_SCF_FBW7_2
138:144
IITPIHE
FBXW7
0.9936
More...