DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IITPIHE
Uniprot ID:
Q92530
Source protein:
Proteasome inhibitor PI31 subunit
Source gene:
PSMF1
Class:
DEG_SCF_FBW7_2
Location:
138:144
E3 ligase:
FBXW7
DEGRON score:
0.9936
ASA_SCORE:
63.9857
COIL:
0.7561
CONS_SCORE:
0.4327
DSS_SCORE:
0.3379
HELIX:
0.1789
FCONS_SCORE:
1.133
RIG_SCORE:
0.7656
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S136P
SIDM00534
Colorectal Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.7222
p.S136P
ACH-000986
Colon/Colorectal Cancer
CCLE
IITPIHE
DEG_SCF_FBW7_2
0.7222
p.S136P
HT-115
large_intestine
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.7222
p.S153I
TCGA-AF-2693
READ
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.5278
p.S153I
DO36766
READ
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.5278
p.W146L
TCGA-80-5608
LUAD
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
TCGA-EE-A20F
SKCM
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO228986
LICA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO23693
LUAD
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.W146L
DO37961
SKCM
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.2778
p.R133C
TCGA-D1-A103
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
TCGA-DX-A8BP
SARC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO233154
GACA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO220056
SARC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133C
DO42312
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
SIDM00741
Small Cell Lung Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
SIDM00251
Gastric Carcinoma
GDSC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
TGBC11TKB
stomach
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.R133H
NCI-H1694
lung
COSMIC
IITPIHE
DEG_SCF_FBW7_2
0.1944
p.N150S
TCGA-EO-A22X
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.1667
p.N150S
DO43907
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1667
p.R131L
DO229019
LICA
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.1389
p.E129K
TCGA-AX-A1CJ
UCEC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.0833
p.E129K
DO40828
UCEC
ICGC
IITPIHE
DEG_SCF_FBW7_2
0.0833
p.P154L
TCGA-DG-A2KK
CESC
TCGA
IITPIHE
DEG_SCF_FBW7_2
0.0556
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Drug responses associated with PSMF1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of IITPIHE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92530
Proteasome inhibitor PI31 subunit
DEG_SCF_FBW7_2
138:144
IITPIHE
FBXW7
0.9936
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