DegronMD - Q9Y5P3(RAI2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S149R	TCGA-51-6867	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7427
p.S149R	DO26477	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7427
p.S147Y	TCGA-55-8506	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.712
p.S147Y	DO45390	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.712
p.G199W	TCGA-66-2734	LUSC	TCGA	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1389
p.P141T	TCGA-86-8073	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.P141T	DO23624	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.P206S	TCGA-B5-A0K4	UCEC	TCGA	PPGY	ITCH	206:209	Mutation altering degron motif	0.6752
p.P206S	DO42360	UCEC	ICGC	PPGY	ITCH	206:209	Mutation altering degron motif	0.6752
p.G199R	TCGA-BR-7723	STAD	TCGA	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1389
p.L155F	TCGA-DI-A1BU	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1667
p.T150N	TCGA-E9-A1RF	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.3056
p.T150N	DO2665	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.3056
p.P207S	TCGA-EE-A2MF	SKCM	TCGA	PPGY	ITCH	206:209	Mutation altering degron motif	0.6752
p.P207S	DO222491	MELA	ICGC	PPGY	ITCH	206:209	Mutation altering degron motif	0.6752
p.P207S	DO51249	SKCM	ICGC	PPGY	ITCH	206:209	Mutation altering degron motif	0.6752
p.E143K	TCGA-EE-A3AA	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2778
p.E143K	DO222632	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2778
p.E143K	DO37571	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2778
p.S147F	TCGA-ER-A19S	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7982
p.S147F	TCGA-ER-A42L	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7982
p.S147T	TCGA-FR-A726	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.6005
p.S147T	DO48665	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.6005
p.G199E	TCGA-FW-A3R5	SKCM	TCGA	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1389
p.G199E	DO37406	SKCM	ICGC	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1389
p.A210T	TCGA-MA-AA42	CESC	TCGA	PPGY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.A210T	DO219724	CESC	ICGC	PPGY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.A144S	DO50341	ESAD	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.3056
p.G149W	DO26430	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7825
p.G158E	DO220881	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0833
p.E135K	DO46436	OV	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0556
p.P214S	DO232224	PBCA	ICGC	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.P214S	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.P214S	ACH-000729	Lung Cancer	CCLE	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.P214S	NCI-H1963	lung	COSMIC	PPGY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.G149R	DO38875	STAD	ICGC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.7568
p.N135D	SIDM00874	Breast Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0556
p.N135D	ACH-000223	Breast Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0556
p.P137H	SIDM01146	Gastric Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1111
p.P137H	ACH-000932	Gastric Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1111
p.P137H	NCI-SNU-1	stomach	COSMIC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1111
p.P145S	SIDM00901	Endometrial Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.6752
p.P145S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.6752
p.P145S	AN3-CA	endometrium	COSMIC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.6752
p.P141Q	ACH-000467	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.P141Q	HCC-56	large intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.S208Y	NCI-H1993	lung	COSMIC	PPGY	ITCH	206:209	Mutation altering degron motif	0.712
p.Q139H	LNZTA3WT4	central nervous system	COSMIC	PCSSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAI2

UniProt ID: Q9Y5P3

Entrez ID: 10742

Protein name: Retinoic acid-induced protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAI2 in