DegronMD - Q07092(COL16A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R701Q	TCGA-AP-A0LM	UCEC	TCGA	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.2778
p.G1555V	TCGA-BG-A222	UCEC	TCGA	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.0556
p.G1555V	DO42977	UCEC	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.0556
p.Q1498H	TCGA-BG-A2L7	UCEC	TCGA	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation rewiring degron network	0.1944
p.Q1498H	DO42344	UCEC	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation rewiring degron network	0.1944
p.G1535S	TCGA-CD-A4MJ	STAD	TCGA	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.G1535S	DO47811	STAD	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.M1548I	TCGA-CV-5977	HNSC	TCGA	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.25
p.M1548I	DO14403	HNSC	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.25
p.A687S	TCGA-D1-A0ZZ	UCEC	TCGA	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.1667
p.P1514S	TCGA-E6-A1LX	UCEC	TCGA	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation rewiring degron network	0.25
p.P1514S	DO41020	UCEC	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation rewiring degron network	0.25
p.P693S	TCGA-FR-A8YC	SKCM	TCGA	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation altering degron motif	0.6752
p.R701W	TCGA-G9-6494	PRAD	TCGA	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.2778
p.G1549C	TCGA-GN-A26C	SKCM	TCGA	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.2222
p.G1549C	DO37782	SKCM	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.2222
p.G1535C	TCGA-UF-A71D	HNSC	TCGA	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.G1535C	DO52109	HNSC	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.S704L	DO1129	BRCA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.1944
p.E1519K	DO48234	ESCA	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation rewiring degron network	0.1111
p.P1537Q	DO228900	LICA	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1944
p.P689T	DO229029	LICA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.2222
p.D691E	DO231813	LINC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.2778
p.P1534L	DO23440	LINC	ICGC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1111
p.T694M	DO36221	PRAD	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation altering degron motif	0.7423
p.R700W	DO36315	PRAD	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.3056
p.P692S	DO50301	SKCM	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.3056
p.G708E	DO229229	THCA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.0833
p.R700Q	DO43306	UCEC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.3056
p.A686S	DO43122	UCEC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.1389
p.G1535A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.G1535A	ACH-000983	Leukemia	CCLE	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.G1535A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1389
p.R1504L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation altering degron motif	0.8428
p.R1504L	ACH-000733	Lung Cancer	CCLE	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation altering degron motif	0.8428
p.R1504L	NCI-H1838	lung	COSMIC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation altering degron motif	0.8428
p.R1504W	SIDM00239	Kidney Carcinoma	GDSC	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation altering degron motif	0.8634
p.R1504W	ACH-000159	Kidney Cancer	CCLE	GRQGLPGVR	DEG_APCC_DBOX_1	1503:1511	Mutation altering degron motif	0.8634
p.G688W	ACH-000816	Lung Cancer	CCLE	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.1944
p.P1536H	ACH-000975	Lung Cancer	CCLE	PPGY	ITCH	1542:1545	Mutation rewiring degron network	0.1667
p.N689Y	ACH-001853	Bile Duct Cancer	CCLE	PGTPGTT	DEG_SCF_FBW7_1	693:699	Mutation rewiring degron network	0.2222

Kaplan plot for COL16A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL16A1

UniProt ID: Q07092

Entrez ID: 1307

Protein name: Collagen alpha-1(XVI) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL16A1 in