DegronMD

Uniprot ID: Q07092

Source protein: Collagen alpha-1

Source gene: COL16A1

Class: DEG_APCC_DBOX_1

Location: 1503:1511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9916

ASA_SCORE: 79.8556

COIL: 0.9513

CONS_SCORE: 0.6088

DSS_SCORE: 0.7497

HELIX: 0.0111

FCONS_SCORE: 1.0061

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1498H	TCGA-BG-A2L7	UCEC	TCGA	GRQGLPGVR	DEG_APCC_DBOX_1	0.1944
p.Q1498H	DO42344	UCEC	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	0.1944
p.P1514S	TCGA-E6-A1LX	UCEC	TCGA	GRQGLPGVR	DEG_APCC_DBOX_1	0.25
p.P1514S	DO41020	UCEC	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	0.25
p.E1519K	DO48234	ESCA	ICGC	GRQGLPGVR	DEG_APCC_DBOX_1	0.1111
p.R1504L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	GRQGLPGVR	DEG_APCC_DBOX_1	0.8428
p.R1504L	ACH-000733	Lung Cancer	CCLE	GRQGLPGVR	DEG_APCC_DBOX_1	0.8428
p.R1504L	NCI-H1838	lung	COSMIC	GRQGLPGVR	DEG_APCC_DBOX_1	0.8428
p.R1504W	SIDM00239	Kidney Carcinoma	GDSC	GRQGLPGVR	DEG_APCC_DBOX_1	0.8634
p.R1504W	ACH-000159	Kidney Cancer	CCLE	GRQGLPGVR	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07092	Collagen alpha-1	DEG_APCC_DBOX_1	1503:1511	GRQGLPGVR	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons