DegronMD

Uniprot ID: Q07092

Source protein: Collagen alpha-1

Source gene: COL16A1

Class: DEG_SCF_FBW7_1

Location: 693:699

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 69.8

COIL: 0.9434

CONS_SCORE: 0.6543

DSS_SCORE: 0.8645

HELIX: 0.007

FCONS_SCORE: 1.1739

RIG_SCORE: 0.513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R701Q	TCGA-AP-A0LM	UCEC	TCGA	PGTPGTT	DEG_SCF_FBW7_1	0.2778
p.A687S	TCGA-D1-A0ZZ	UCEC	TCGA	PGTPGTT	DEG_SCF_FBW7_1	0.1667
p.P693S	TCGA-FR-A8YC	SKCM	TCGA	PGTPGTT	DEG_SCF_FBW7_1	0.6752
p.R701W	TCGA-G9-6494	PRAD	TCGA	PGTPGTT	DEG_SCF_FBW7_1	0.2778
p.S704L	DO1129	BRCA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.1944
p.P689T	DO229029	LICA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.2222
p.D691E	DO231813	LINC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.2778
p.T694M	DO36221	PRAD	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.7423
p.R700W	DO36315	PRAD	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.3056
p.P692S	DO50301	SKCM	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.3056
p.G708E	DO229229	THCA	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.0833
p.R700Q	DO43306	UCEC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.3056
p.A686S	DO43122	UCEC	ICGC	PGTPGTT	DEG_SCF_FBW7_1	0.1389
p.G688W	ACH-000816	Lung Cancer	CCLE	PGTPGTT	DEG_SCF_FBW7_1	0.1944
p.N689Y	ACH-001853	Bile Duct Cancer	CCLE	PGTPGTT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07092	Collagen alpha-1	DEG_SCF_FBW7_1	693:699	PGTPGTT	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons