DegronMD - P35713(SOX18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A228T	DO229005	COCA	ICGC	ERSPLDGLE	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2222
p.A228T	DO229005	COCA	ICGC	LPTPERS	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.0556
p.E227K	DO15791	HNSC	ICGC	ERSPLDGLE	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.25
p.E227K	DO15791	HNSC	ICGC	LPTPERS	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.0833
p.D208N	SIDM01943	Colorectal Carcinoma	GDSC	ERSPLDGLE	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1111
p.D208N	SIDM01943	Colorectal Carcinoma	GDSC	LPTPERS	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.2222
p.A16S	SIDM00845	Burkitt's Lymphoma	GDSC	PPGY	ITCH	5:8	Mutation rewiring degron network	0.1111
p.L223Q	ACH-000493	Liver Cancer	CCLE	ERSPLDGLE	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7765
p.E206K	ACH-000940	Endometrial/Uterine Cancer	CCLE	ERSPLDGLE	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.0556
p.E206K	ACH-000940	Endometrial/Uterine Cancer	CCLE	LPTPERS	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons