DegronMD

Uniprot ID: P35713

Source protein: Transcription factor SOX-18

Source gene: SOX18

Class: DEG_SCF_FBW7_1

Location: 212:218

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 50.4857

COIL: 0.9367

CONS_SCORE: 0.6202

DSS_SCORE: 0.6645

HELIX: 0.0184

FCONS_SCORE: 1.4079

RIG_SCORE: 0.6488

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D208N	SIDM01943	Colorectal Carcinoma	GDSC	LPTPERS	DEG_SCF_FBW7_1	0.2222
p.E206K	ACH-000940	Endometrial/Uterine Cancer	CCLE	LPTPERS	DEG_SCF_FBW7_1	0.1667
p.E227K	DO15791	HNSC	ICGC	LPTPERS	DEG_SCF_FBW7_1	0.0833
p.A228T	DO229005	COCA	ICGC	LPTPERS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35713	Transcription factor SOX-18	DEG_SCF_FBW7_1	212:218	LPTPERS	FBXW7	0.998	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons