DegronMD

Uniprot ID: P35713

Source protein: Transcription factor SOX-18

Source gene: SOX18

Class: DEG_APCC_DBOX_1

Location: 216:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9894

ASA_SCORE: 60.6

COIL: 0.8926

CONS_SCORE: 0.5445

DSS_SCORE: 0.6661

HELIX: 0.0741

FCONS_SCORE: 1.1394

RIG_SCORE: 0.6405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A228T	DO229005	COCA	ICGC	ERSPLDGLE	DEG_APCC_DBOX_1	0.2222
p.E227K	DO15791	HNSC	ICGC	ERSPLDGLE	DEG_APCC_DBOX_1	0.25
p.D208N	SIDM01943	Colorectal Carcinoma	GDSC	ERSPLDGLE	DEG_APCC_DBOX_1	0.1111
p.L223Q	ACH-000493	Liver Cancer	CCLE	ERSPLDGLE	DEG_APCC_DBOX_1	0.7765
p.E206K	ACH-000940	Endometrial/Uterine Cancer	CCLE	ERSPLDGLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35713	Transcription factor SOX-18	DEG_APCC_DBOX_1	216:224	ERSPLDGLE	APC,CDC20,FZR1	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons