DegronMD - P53420(COL4A4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1310R	TCGA-18-5592	LUSC	TCGA	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6457
p.G1310R	DO23106	LINC	ICGC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6457
p.G1310R	DO26432	LUSC	ICGC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6457
p.G1307D	TCGA-AA-3506	COAD	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.3056
p.G1307D	DO8063	COAD	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.3056
p.G1127E	TCGA-B5-A0K9	UCEC	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1111
p.G1127E	DO42097	UCEC	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1111
p.P1117H	TCGA-BS-A0U8	UCEC	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6583
p.P1117H	DO228974	LICA	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6583
p.P1117H	DO41380	UCEC	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6583
p.G1112W	TCGA-CV-6936	HNSC	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6714
p.G1112W	DO14210	HNSC	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6714
p.P1315S	TCGA-EB-A4XL	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.P1315S	DO47401	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.R1114I	TCGA-ER-A19P	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.8102
p.R1114I	DO47623	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.8102
p.G1304A	TCGA-EY-A1GS	UCEC	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.G1304A	DO43162	UCEC	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.G1319E	TCGA-FW-A3R5	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1111
p.G1319E	DO37406	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1111
p.P1309S	TCGA-FW-A3R5	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6752
p.P1309S	DO37406	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6752
p.P1309S	DO229211	THCA	ICGC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6752
p.S1125F	TCGA-FW-A3R5	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1667
p.S1125F	DO37406	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1667
p.P1123L	TCGA-GN-A266	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2222
p.P1123L	DO37432	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2222
p.G1304D	TCGA-OD-A75X	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.G1304D	DO48601	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.2222
p.G1121R	TCGA-W3-A825	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2778
p.G1121R	DO51272	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2778
p.P1299S	TCGA-W3-AA1R	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.0833
p.P1299S	DO51275	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.0833
p.P1302L	TCGA-Z2-A8RT	SKCM	TCGA	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1667
p.P1302L	DO51301	SKCM	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1667
p.G1103R	DO221192	AML	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	SIDM00151	Ovarian Carcinoma	GDSC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	ACH-000960	Leukemia	CCLE	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	ACH-000966	Ovarian Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	IGROV-1	ovary	COSMIC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1103R	REH	haematopoietic and lymphoid tissue	COSMIC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.1389
p.G1319R	DO50968	LICA	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1111
p.G1319R	DO220891	MELA	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1111
p.G1118R	DO23236	LINC	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6457
p.P1117S	DO23202	LINC	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.5641
p.P1117S	SIDM00140	Melanoma	GDSC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.5641
p.P1117S	ACH-000968	Skin Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.5641
p.P1117S	COLO-792	skin	COSMIC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.5641
p.P1305L	DO228880	MALY	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.25
p.G1118E	DO222875	MELA	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.6087
p.D1318Y	DO50729	ORCA	ICGC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.1389
p.G1106C	DO229275	THCA	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2222
p.G1121V	DO229242	THCA	ICGC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.2778
p.G1310A	SIDM01174	Cervical Carcinoma	GDSC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6429
p.G1310A	ACH-001402	Cervical Cancer	CCLE	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6429
p.G1310A	SW756	cervix	COSMIC	PPGY	ITCH	1308:1311	Mutation altering degron motif	0.6429
p.G1115R	SIDM00149	Melanoma	GDSC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.7568
p.G1115R	ACH-000750	Skin Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.7568
p.G1115R	LOXIMVI	skin	COSMIC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation altering degron motif	0.7568
p.P1305S	SIDM00140	Melanoma	GDSC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.25
p.P1305S	ACH-000968	Skin Cancer	CCLE	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.25
p.P1305S	COLO-792	skin	COSMIC	PPGY	ITCH	1308:1311	Mutation rewiring degron network	0.25
p.L1107F	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.25
p.L1107F	ACH-000727	Lung Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.25
p.L1107F	NCI-H2066	lung	COSMIC	IQGPRGSPGR	SCF_FBXL2	1110:1119	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A4

UniProt ID: P53420

Entrez ID: 1286

Protein name: Collagen alpha-4(IV) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A4 in