DegronMD

Uniprot ID: P53420

Source protein: Collagen alpha-4

Source gene: COL4A4

Class: SCF_FBXL2

Location: 1110:1119

E3 ligase: FBXL2

DEGRON score: 0.8096

ASA_SCORE: 82.89

COIL: 0.9481

CONS_SCORE: 0.4414

DSS_SCORE: 0.9127

HELIX: 0.0104

FCONS_SCORE: 0.7824

RIG_SCORE: 0.4801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1127E	TCGA-B5-A0K9	UCEC	TCGA	IQGPRGSPGR	SCF_FBXL2	0.1111
p.G1127E	DO42097	UCEC	ICGC	IQGPRGSPGR	SCF_FBXL2	0.1111
p.P1117H	TCGA-BS-A0U8	UCEC	TCGA	IQGPRGSPGR	SCF_FBXL2	0.6583
p.P1117H	DO228974	LICA	ICGC	IQGPRGSPGR	SCF_FBXL2	0.6583
p.P1117H	DO41380	UCEC	ICGC	IQGPRGSPGR	SCF_FBXL2	0.6583
p.G1112W	TCGA-CV-6936	HNSC	TCGA	IQGPRGSPGR	SCF_FBXL2	0.6714
p.G1112W	DO14210	HNSC	ICGC	IQGPRGSPGR	SCF_FBXL2	0.6714
p.R1114I	TCGA-ER-A19P	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	0.8102
p.R1114I	DO47623	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	0.8102
p.S1125F	TCGA-FW-A3R5	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	0.1667
p.S1125F	DO37406	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	0.1667
p.P1123L	TCGA-GN-A266	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	0.2222
p.P1123L	DO37432	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	0.2222
p.G1121R	TCGA-W3-A825	SKCM	TCGA	IQGPRGSPGR	SCF_FBXL2	0.2778
p.G1121R	DO51272	SKCM	ICGC	IQGPRGSPGR	SCF_FBXL2	0.2778
p.G1103R	DO221192	AML	ICGC	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	SIDM00151	Ovarian Carcinoma	GDSC	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	ACH-000960	Leukemia	CCLE	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	ACH-000966	Ovarian Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	IGROV-1	ovary	COSMIC	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1103R	REH	haematopoietic_and_lymphoid_tissue	COSMIC	IQGPRGSPGR	SCF_FBXL2	0.1389
p.G1118R	DO23236	LINC	ICGC	IQGPRGSPGR	SCF_FBXL2	0.6457
p.P1117S	DO23202	LINC	ICGC	IQGPRGSPGR	SCF_FBXL2	0.5641
p.P1117S	SIDM00140	Melanoma	GDSC	IQGPRGSPGR	SCF_FBXL2	0.5641
p.P1117S	ACH-000968	Skin Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	0.5641
p.P1117S	COLO-792	skin	COSMIC	IQGPRGSPGR	SCF_FBXL2	0.5641
p.G1118E	DO222875	MELA	ICGC	IQGPRGSPGR	SCF_FBXL2	0.6087
p.G1106C	DO229275	THCA	ICGC	IQGPRGSPGR	SCF_FBXL2	0.2222
p.G1121V	DO229242	THCA	ICGC	IQGPRGSPGR	SCF_FBXL2	0.2778
p.G1115R	SIDM00149	Melanoma	GDSC	IQGPRGSPGR	SCF_FBXL2	0.7568
p.G1115R	ACH-000750	Skin Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	0.7568
p.G1115R	LOXIMVI	skin	COSMIC	IQGPRGSPGR	SCF_FBXL2	0.7568
p.L1107F	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	IQGPRGSPGR	SCF_FBXL2	0.25
p.L1107F	ACH-000727	Lung Cancer	CCLE	IQGPRGSPGR	SCF_FBXL2	0.25
p.L1107F	NCI-H2066	lung	COSMIC	IQGPRGSPGR	SCF_FBXL2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQGPRGSPGR

Degron related mutations and impact score

Drug responses associated with COL4A4 mutations

All proteins holding degron of IQGPRGSPGR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53420	Collagen alpha-4	SCF_FBXL2	1110:1119	IQGPRGSPGR	FBXL2	0.8096	More...