DegronMD - P25940(COL5A3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G716V	TCGA-06-1805	GBM	TCGA	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1111
p.G716V	DO11567	GBM	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1111
p.R712W	TCGA-17-Z026	LUAD	TCGA	PPGY	ITCH	705:708	Mutation rewiring degron network	0.2222
p.P299L	TCGA-29-1691	OV	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	DO32133	OV	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P706T	TCGA-29-1761	OV	TCGA	PPGY	ITCH	705:708	Mutation altering degron motif	0.7031
p.P706T	DO32207	OV	ICGC	PPGY	ITCH	705:708	Mutation altering degron motif	0.7031
p.R243H	TCGA-49-6743	LUAD	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	DO234340	ESAD	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	DO26092	LUAD	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00371	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00544	Neuroblastoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00567	Other Solid Cancers	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00612	Glioma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00997	Thyroid Gland Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00618	Hepatocellular Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM00469	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM01498	Acute Myeloid Leukemia	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM01660	Kidney Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243C	TCGA-97-7546	LUAD	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.R243C	DO23762	LUAD	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1389
p.P699T	TCGA-A5-A0G1	UCEC	TCGA	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1667
p.P699T	DO42472	UCEC	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1667
p.V311L	TCGA-A5-A0R6	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.3056
p.V311L	DO41145	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.3056
p.D223N	TCGA-B5-A0JY	UCEC	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1944
p.D223N	DO43041	UCEC	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1944
p.T313A	TCGA-C5-A1MH	CESC	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.T313A	DO48982	CESC	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.A230T	TCGA-CA-6717	COAD	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6028
p.A230T	TCGA-FR-A8YC	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6028
p.A230T	DO8264	COAD	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6028
p.A230T	DO50301	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6028
p.P244S	TCGA-D9-A6EC	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.P244S	TCGA-FW-A3R5	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.P244S	DO37406	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.P244S	DO50291	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.R219W	TCGA-DE-A4MB	THCA	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.R219W	DO38964	THCA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.G695R	TCGA-DK-A6B0	BLCA	TCGA	PPGY	ITCH	705:708	Mutation rewiring degron network	0.0556
p.G695R	DO48501	BLCA	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.0556
p.Q236E	TCGA-E3-A3E3	THCA	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.5633
p.Q236E	DO38927	THCA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.5633
p.T303M	TCGA-EA-A3HS	CESC	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.T303M	DO6260	CESC	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.T303M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.T303M	ACH-002267	Leukemia	CCLE	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.T303M	LC4-1	haematopoietic and lymphoid tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.P296L	TCGA-EE-A29S	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.P296L	DO37936	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.P711L	TCGA-EE-A2GI	SKCM	TCGA	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.P711L	DO37410	SKCM	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.P711L	SIDM01060	Melanoma	GDSC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.P711L	ACH-000882	Skin Cancer	CCLE	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.P711L	IGR-1	skin	COSMIC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.V233L	TCGA-EO-A22X	UCEC	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6765
p.V233L	DO43907	UCEC	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6765
p.P244L	TCGA-FW-A3R5	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.P244L	DO37406	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.1111
p.S309F	TCGA-Z2-A8RT	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7982
p.S309F	DO51301	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7982
p.R245W	DO224598	BRCA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.R245W	DO1010	BRCA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.R246W	DO228129	EOPC	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0556
p.P699S	DO50441	ESAD	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1667
p.R219Q	DO222285	GACA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.A234D	DO229029	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6682
p.T232K	DO229022	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6195
p.A228E	DO229041	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.659
p.P235S	DO220862	MELA	ICGC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation altering degron motif	0.6752
p.G698S	DO220906	MELA	ICGC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1389
p.P705S	DO222875	MELA	ICGC	PPGY	ITCH	705:708	Mutation altering degron motif	0.6752
p.V306F	DO49166	PACA	ICGC	VVTST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7068
p.R245Q	SIDM02049	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	228:236	Mutation rewiring degron network	0.0833
p.G713R	SIDM00108	Melanoma	GDSC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1944
p.G713R	ACH-000579	Skin Cancer	CCLE	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1944
p.G713R	UACC-257	skin	COSMIC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.1944
p.A703T	SIDM00499	Prostate Carcinoma	GDSC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.2778
p.S702L	SIDM00223	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25
p.S702L	IST-SL1	lung	COSMIC	PPGY	ITCH	705:708	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL5A3

UniProt ID: P25940

Entrez ID: 50509

Protein name: Collagen alpha-3(V) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL5A3 in