DegronMD

Uniprot ID: P25940

Source protein: Collagen alpha-3

Source gene: COL5A3

Class: DEG_SIAH_1

Location: 228:236

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9778

ASA_SCORE: 67.3556

COIL: 0.8616

CONS_SCORE: 0.2423

DSS_SCORE: 0.6121

HELIX: 0.0694

FCONS_SCORE: 0.9224

RIG_SCORE: 0.6758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R243H	TCGA-49-6743	LUAD	TCGA	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	DO234340	ESAD	ICGC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	DO26092	LUAD	ICGC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00371	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00544	Neuroblastoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00567	Other Solid Cancers	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00612	Glioma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00997	Thyroid Gland Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00618	Hepatocellular Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM00469	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM01498	Acute Myeloid Leukemia	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM01660	Kidney Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243C	TCGA-97-7546	LUAD	TCGA	APAATVAPQ	DEG_SIAH_1	0.1389
p.R243C	DO23762	LUAD	ICGC	APAATVAPQ	DEG_SIAH_1	0.1389
p.D223N	TCGA-B5-A0JY	UCEC	TCGA	APAATVAPQ	DEG_SIAH_1	0.1944
p.D223N	DO43041	UCEC	ICGC	APAATVAPQ	DEG_SIAH_1	0.1944
p.A230T	TCGA-CA-6717	COAD	TCGA	APAATVAPQ	DEG_SIAH_1	0.6028
p.A230T	TCGA-FR-A8YC	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	0.6028
p.A230T	DO8264	COAD	ICGC	APAATVAPQ	DEG_SIAH_1	0.6028
p.A230T	DO50301	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	0.6028
p.P244S	TCGA-D9-A6EC	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	0.1111
p.P244S	TCGA-FW-A3R5	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	0.1111
p.P244S	DO37406	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	0.1111
p.P244S	DO50291	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	0.1111
p.R219W	TCGA-DE-A4MB	THCA	TCGA	APAATVAPQ	DEG_SIAH_1	0.0833
p.R219W	DO38964	THCA	ICGC	APAATVAPQ	DEG_SIAH_1	0.0833
p.Q236E	TCGA-E3-A3E3	THCA	TCGA	APAATVAPQ	DEG_SIAH_1	0.5633
p.Q236E	DO38927	THCA	ICGC	APAATVAPQ	DEG_SIAH_1	0.5633
p.V233L	TCGA-EO-A22X	UCEC	TCGA	APAATVAPQ	DEG_SIAH_1	0.6765
p.V233L	DO43907	UCEC	ICGC	APAATVAPQ	DEG_SIAH_1	0.6765
p.P244L	TCGA-FW-A3R5	SKCM	TCGA	APAATVAPQ	DEG_SIAH_1	0.1111
p.P244L	DO37406	SKCM	ICGC	APAATVAPQ	DEG_SIAH_1	0.1111
p.R245W	DO224598	BRCA	ICGC	APAATVAPQ	DEG_SIAH_1	0.0833
p.R245W	DO1010	BRCA	ICGC	APAATVAPQ	DEG_SIAH_1	0.0833
p.R246W	DO228129	EOPC	ICGC	APAATVAPQ	DEG_SIAH_1	0.0556
p.R219Q	DO222285	GACA	ICGC	APAATVAPQ	DEG_SIAH_1	0.0833
p.A234D	DO229029	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	0.6682
p.T232K	DO229022	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	0.6195
p.A228E	DO229041	LICA	ICGC	APAATVAPQ	DEG_SIAH_1	0.659
p.P235S	DO220862	MELA	ICGC	APAATVAPQ	DEG_SIAH_1	0.6752
p.R245Q	SIDM02049	Pancreatic Carcinoma	GDSC	APAATVAPQ	DEG_SIAH_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APAATVAPQ

Degron related mutations and impact score

Drug responses associated with COL5A3 mutations

All proteins holding degron of APAATVAPQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25940	Collagen alpha-3	DEG_SIAH_1	228:236	APAATVAPQ	SIAH1,SIAH2,SIAH3	0.9778	More...