DegronMD

Uniprot ID: P25940

Source protein: Collagen alpha-3

Source gene: COL5A3

Class: DEG_SPOP_SBC_1

Location: 306:310

E3 ligase: SPOP

DEGRON score: 0.9957

ASA_SCORE: 74.02

COIL: 0.8814

CONS_SCORE: 0.2759

DSS_SCORE: 0.5569

HELIX: 0.0238

FCONS_SCORE: 0.985

RIG_SCORE: 0.798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P299L	TCGA-29-1691	OV	TCGA	VVTST	DEG_SPOP_SBC_1	0.1389
p.P299L	DO32133	OV	ICGC	VVTST	DEG_SPOP_SBC_1	0.1389
p.V311L	TCGA-A5-A0R6	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	0.3056
p.V311L	DO41145	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.T313A	TCGA-C5-A1MH	CESC	TCGA	VVTST	DEG_SPOP_SBC_1	0.25
p.T313A	DO48982	CESC	ICGC	VVTST	DEG_SPOP_SBC_1	0.25
p.T303M	TCGA-EA-A3HS	CESC	TCGA	VVTST	DEG_SPOP_SBC_1	0.25
p.T303M	DO6260	CESC	ICGC	VVTST	DEG_SPOP_SBC_1	0.25
p.T303M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VVTST	DEG_SPOP_SBC_1	0.25
p.T303M	ACH-002267	Leukemia	CCLE	VVTST	DEG_SPOP_SBC_1	0.25
p.T303M	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	0.25
p.P296L	TCGA-EE-A29S	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	0.0556
p.P296L	DO37936	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.0556
p.S309F	TCGA-Z2-A8RT	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	0.7982
p.S309F	DO51301	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.7982
p.V306F	DO49166	PACA	ICGC	VVTST	DEG_SPOP_SBC_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons