DegronMD

Uniprot ID: Q96L42

Source protein: Potassium voltage-gated channel subfamily H member 8

Source gene: KCNH8

Class: DEG_SPOP_SBC_1

Location: 1092:1096

E3 ligase: SPOP

DEGRON score: 0.7903

ASA_SCORE: 61.42

COIL: 0.6344

CONS_SCORE: 0.4415

DSS_SCORE: 0.3893

HELIX: 0.0828

FCONS_SCORE: 1.11

RIG_SCORE: 0.8049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1106K	TCGA-79-5596	LUSC	TCGA	VVTST	DEG_SPOP_SBC_1	0.0556
p.N1106K	DO27357	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	0.0556
p.N1102K	TCGA-95-7039	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.1667
p.N1102K	DO23907	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.1667
p.D1101Y	TCGA-CN-A497	HNSC	TCGA	VVTST	DEG_SPOP_SBC_1	0.1944
p.D1101Y	DO8898	COAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.D1101Y	DO218992	HNSC	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.K1103N	TCGA-EO-A3KX	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	0.25
p.K1103N	DO219774	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.25
p.P1084T	DO48236	ESCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.P1089L	SIDM00475	Ovarian Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.25
p.P1089L	ACH-000091	Ovarian Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.25
p.P1089L	OV-56	ovary	COSMIC	VVTST	DEG_SPOP_SBC_1	0.25
p.N1106H	SIDM00282	Colorectal Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.0556
p.N1106H	ACH-000998	Colon/Colorectal Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.0556
p.N1106H	CW-2	large_intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons