DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SPOP_SBC_1

Location: 15779:15783

E3 ligase: SPOP

DEGRON score: 0.5021

ASA_SCORE: 48.36

COIL: 0.3452

CONS_SCORE: 0.513

DSS_SCORE: 0.1973

HELIX: 0.028

FCONS_SCORE: 0.9975

RIG_SCORE: 0.8966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A15788V	TCGA-B5-A1MX	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	0.3056
p.D15785N	TCGA-CD-A48A	STAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.2778
p.D15774N	DO50464	BOCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.D15774N	DO41379	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.C15787S	DO51551	KIRP	ICGC	VVTST	DEG_SPOP_SBC_1	0.2222
p.T15783K	DO229028	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	0.7306
p.D15774E	DO27660	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.V15779A	DO31330	OV	ICGC	VVTST	DEG_SPOP_SBC_1	0.5825
p.R15785I	DO36881	READ	ICGC	VVTST	DEG_SPOP_SBC_1	0.2778
p.T15792P	DO51795	STAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.0833
p.R15772L	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.25
p.D15769G	SIDM00151	Ovarian Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.0556
p.D15769G	IGROV-1	ovary	COSMIC	VVTST	DEG_SPOP_SBC_1	0.0556
p.V15780F	NCI-H2171	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	0.5957
p.L15780F	MZ7-mel	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons