DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VVTST
Uniprot ID:
Q9P266
Source protein:
Junctional protein associated with coronary artery disease
Source gene:
JCAD
Class:
DEG_SPOP_SBC_1
Location:
1181:1185
E3 ligase:
SPOP
DEGRON score:
0.6941
ASA_SCORE:
86.42
COIL:
0.6898
CONS_SCORE:
0.3335
DSS_SCORE:
0.6683
HELIX:
0.0112
FCONS_SCORE:
0.9078
RIG_SCORE:
0.6484
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1185R
SIDM00937
Oral Cavity Carcinoma
GDSC
VVTST
DEG_SPOP_SBC_1
0.7876
p.T1185R
CAL-27
upper_aerodigestive_tract
COSMIC
VVTST
DEG_SPOP_SBC_1
0.7876
Drug responses associated with JCAD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P15408
Fos-related antigen 2
DEG_SPOP_SBC_1
266:270
VVTST
SPOP
0.9977
More...
P25940
Collagen alpha-3
DEG_SPOP_SBC_1
306:310
VVTST
SPOP
0.9957
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2546:2550
VVTST
SPOP
0.7708
More...
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
1870:1874
VVTST
SPOP
0.9754
More...
Q8WZ42
Titin
DEG_SPOP_SBC_1
15779:15783
VVTST
SPOP
0.5021
More...
Q96L42
Potassium voltage-gated channel subfamily H member 8
DEG_SPOP_SBC_1
1092:1096
VVTST
SPOP
0.7903
More...
Q9P266
Junctional protein associated with coronary artery disease
DEG_SPOP_SBC_1
1181:1185
VVTST
SPOP
0.6941
More...