DegronMD

Uniprot ID: Q8NFC6

Source protein: Biorientation of chromosomes in cell division protein 1-like 1

Source gene: BOD1L1

Class: DEG_SPOP_SBC_1

Location: 1870:1874

E3 ligase: SPOP

DEGRON score: 0.9754

ASA_SCORE: 79.26

COIL: 0.6576

CONS_SCORE: 0.6467

DSS_SCORE: 0.7127

HELIX: 0.0376

FCONS_SCORE: 1.1251

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1869Y	TCGA-55-8299	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.3056
p.D1869Y	DO25927	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.E1879K	TCGA-66-2768	LUSC	TCGA	VVTST	DEG_SPOP_SBC_1	0.1944
p.E1879K	DO50970	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.E1879K	DO27216	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.G1881V	TCGA-99-AA5R	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.1389
p.G1881V	DO51203	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.1389
p.G1867R	TCGA-EE-A2GJ	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	0.25
p.G1867R	DO37746	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.25
p.S1873N	TCGA-ZF-A9RM	BLCA	TCGA	VVTST	DEG_SPOP_SBC_1	0.7069
p.S1873N	DO219079	BLCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.7069
p.T1872S	ACH-001853	Bile Duct Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons