DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2546:2550

E3 ligase: SPOP

DEGRON score: 0.7708

ASA_SCORE: 83.96

COIL: 0.7

CONS_SCORE: 0.5236

DSS_SCORE: 0.5572

HELIX: 0.0124

FCONS_SCORE: 1

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2558P	TCGA-AB-2828	LAML	TCGA	VVTST	DEG_SPOP_SBC_1	0.1111
p.S2558P	DO21571	LAML	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.S2536P	TCGA-AG-3902	READ	TCGA	VVTST	DEG_SPOP_SBC_1	0.0556
p.S2536P	DO36407	READ	ICGC	VVTST	DEG_SPOP_SBC_1	0.0556
p.P2545L	TCGA-BR-8060	STAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.3056
p.P2545L	DO38205	STAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.E2551K	TCGA-DS-A1OD	CESC	TCGA	VVTST	DEG_SPOP_SBC_1	0.3056
p.E2551K	DO6299	CESC	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.E2551Q	DO48371	BLCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.T2538P	DO234212	ESAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.V2547I	DO228945	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	0.5965
p.S2544I	DO229018	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	0.2778
p.V2540I	DO222714	MELA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1667
p.E2551G	DO46909	RECA	ICGC	VVTST	DEG_SPOP_SBC_1	0.3056
p.T2557I	Sarc9371	bone	COSMIC	VVTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons