DegronMD - Q96L42(KCNH8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R166G	TCGA-24-2280	OV	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166G	DO28511	OV	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.N1106K	TCGA-79-5596	LUSC	TCGA	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.N1106K	DO27357	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.N1102K	TCGA-95-7039	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1667
p.N1102K	DO23907	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1667
p.S167R	TCGA-97-8174	LUAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6316
p.S167R	DO25199	LUAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6316
p.R166W	TCGA-AA-3864	COAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166W	TCGA-CM-4744	COAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166W	DO8882	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166W	DO8490	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166W	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.R166W	ACH-000912	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.K185T	TCGA-B5-A1MR	UCEC	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation substituting flanking lysine	0.1667
p.K185T	DO41758	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation substituting flanking lysine	0.1667
p.S1013A	TCGA-BS-A0UV	UCEC	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1389
p.S1013A	DO42793	UCEC	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1389
p.D1101Y	TCGA-CN-A497	HNSC	TCGA	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1944
p.D1101Y	DO8898	COAD	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1944
p.D1101Y	DO218992	HNSC	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1944
p.S1018Y	TCGA-D1-A103	UCEC	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.2778
p.S1018Y	DO42312	UCEC	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.2778
p.D1017N	TCGA-EE-A29D	SKCM	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.25
p.D1017N	DO38123	SKCM	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.25
p.P1014L	TCGA-EE-A29L	SKCM	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1667
p.P1014L	DO220886	MELA	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1667
p.P1014L	DO222599	MELA	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1667
p.P1014L	DO37835	SKCM	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1667
p.K183N	TCGA-EO-A3AV	UCEC	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation substituting flanking lysine	0.2222
p.K183N	DO52412	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation substituting flanking lysine	0.2222
p.K1103N	TCGA-EO-A3KX	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation substituting flanking lysine	0.25
p.K1103N	DO219774	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation substituting flanking lysine	0.25
p.H173Y	TCGA-OD-A75X	SKCM	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6118
p.H173Y	DO48601	SKCM	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6118
p.S1016L	TCGA-QC-A7B5	SARC	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.2222
p.S1016L	DO220239	SARC	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.2222
p.T1019M	TCGA-XK-AAIW	PRAD	TCGA	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.3056
p.T1019M	DO51407	PRAD	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.3056
p.R164H	DO3095	BRCA	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.D161Y	DO7783	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1667
p.L1030V	DO48282	ESCA	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.P1084T	DO48236	ESCA	ICGC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1111
p.R175M	DO50847	LICA	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.8632
p.H1015Q	DO228338	MALY	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.H1015Q	SIDM00948	Burkitt's Lymphoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.H1015Q	ACH-002232	Lymphoma	CCLE	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.H1015Q	DG-75	haematopoietic and lymphoid tissue	COSMIC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.N184K	DO46329	OV	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0833
p.S1032F	DO51493	PACA	ICGC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1389
p.F162C	DO41020	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.L177F	DO41199	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.H177Y	DO41199	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.G157V	SIDM01156	Small Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.G157V	ACH-000890	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.G157V	SW1271	lung	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.G157W	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.G157W	ACH-000924	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.G157W	NCI-H2172	lung	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.I174M	SIDM00803	Kidney Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6507
p.I174M	ACH-000411	Kidney Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6507
p.I174M	769-P	kidney	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6507
p.P1089L	SIDM00475	Ovarian Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.25
p.P1089L	ACH-000091	Ovarian Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.25
p.P1089L	OV-56	ovary	COSMIC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.25
p.T1021M	SIDM00466	Ovarian Carcinoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation altering degron motif	0.7423
p.N1106H	SIDM00282	Colorectal Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.N1106H	ACH-000998	Colon/Colorectal Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.N1106H	CW-2	large intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.L1030R	SIDM01611	Endometrial Carcinoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944
p.L1030R	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTPLQS	DEG_SCF_FBW7_1	1020:1025	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH8

UniProt ID: Q96L42

Entrez ID: 131096

Protein name: Potassium voltage-gated channel subfamily H member 8 (ELK1) (hElk1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH8 in