DegronMD

Uniprot ID: Q96L42

Source protein: Potassium voltage-gated channel subfamily H member 8

Source gene: KCNH8

Class: DEG_SCF_FBW7_1

Location: 1020:1025

E3 ligase: FBXW7

DEGRON score: 0.5461

ASA_SCORE: 87.3

COIL: 0.8453

CONS_SCORE: 0.4443

DSS_SCORE: 0.323

HELIX: 0.0422

FCONS_SCORE: 1.022

RIG_SCORE: 0.7486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1013A	TCGA-BS-A0UV	UCEC	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.1389
p.S1013A	DO42793	UCEC	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1389
p.S1018Y	TCGA-D1-A103	UCEC	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.2778
p.S1018Y	DO42312	UCEC	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.2778
p.D1017N	TCGA-EE-A29D	SKCM	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.25
p.D1017N	DO38123	SKCM	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.25
p.P1014L	TCGA-EE-A29L	SKCM	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.1667
p.P1014L	DO220886	MELA	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1667
p.P1014L	DO222599	MELA	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1667
p.P1014L	DO37835	SKCM	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1667
p.S1016L	TCGA-QC-A7B5	SARC	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.2222
p.S1016L	DO220239	SARC	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.2222
p.T1019M	TCGA-XK-AAIW	PRAD	TCGA	LTPLQS	DEG_SCF_FBW7_1	0.3056
p.T1019M	DO51407	PRAD	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.3056
p.L1030V	DO48282	ESCA	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.H1015Q	DO228338	MALY	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.H1015Q	SIDM00948	Burkitt's Lymphoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.H1015Q	ACH-002232	Lymphoma	CCLE	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.H1015Q	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.S1032F	DO51493	PACA	ICGC	LTPLQS	DEG_SCF_FBW7_1	0.1389
p.T1021M	SIDM00466	Ovarian Carcinoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	0.7423
p.L1030R	SIDM01611	Endometrial Carcinoma	GDSC	LTPLQS	DEG_SCF_FBW7_1	0.1944
p.L1030R	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTPLQS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SCF_FBW7_1	1020:1025	LTPLQS	FBXW7	0.5461	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons