DegronMD

Uniprot ID: Q96L42

Source protein: Potassium voltage-gated channel subfamily H member 8

Source gene: KCNH8

Class: DEG_APCC_DBOX_1

Location: 167:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.85

ASA_SCORE: 80.6

COIL: 0.5511

CONS_SCORE: 0.5826

DSS_SCORE: 0.4599

HELIX: 0.2209

FCONS_SCORE: 1.2183

RIG_SCORE: 0.7656

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R166G	TCGA-24-2280	OV	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166G	DO28511	OV	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.S167R	TCGA-97-8174	LUAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.6316
p.S167R	DO25199	LUAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.6316
p.R166W	TCGA-AA-3864	COAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166W	TCGA-CM-4744	COAD	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166W	DO8882	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166W	DO8490	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166W	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.R166W	ACH-000912	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	0.3056
p.K185T	TCGA-B5-A1MR	UCEC	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.1667
p.K185T	DO41758	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.1667
p.K183N	TCGA-EO-A3AV	UCEC	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.2222
p.K183N	DO52412	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.2222
p.H173Y	TCGA-OD-A75X	SKCM	TCGA	SRAVLYHIS	DEG_APCC_DBOX_1	0.6118
p.H173Y	DO48601	SKCM	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.6118
p.R164H	DO3095	BRCA	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.25
p.D161Y	DO7783	COAD	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.1667
p.R175M	DO50847	LICA	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.8632
p.N184K	DO46329	OV	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.0833
p.F162C	DO41020	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.1944
p.L177F	DO41199	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.2778
p.H177Y	DO41199	UCEC	ICGC	SRAVLYHIS	DEG_APCC_DBOX_1	0.2778
p.G157V	SIDM01156	Small Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.G157V	ACH-000890	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.G157V	SW1271	lung	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.G157W	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.G157W	ACH-000924	Lung Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.G157W	NCI-H2172	lung	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	0.0556
p.I174M	SIDM00803	Kidney Carcinoma	GDSC	SRAVLYHIS	DEG_APCC_DBOX_1	0.6507
p.I174M	ACH-000411	Kidney Cancer	CCLE	SRAVLYHIS	DEG_APCC_DBOX_1	0.6507
p.I174M	769-P	kidney	COSMIC	SRAVLYHIS	DEG_APCC_DBOX_1	0.6507

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRAVLYHIS

Degron related mutations and impact score

Drug responses associated with KCNH8 mutations

All proteins holding degron of SRAVLYHIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_APCC_DBOX_1	167:175	SRAVLYHIS	APC,CDC20,FZR1	0.85	More...