DegronMD - B1AK53(ESPN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S362W	TCGA-93-8067	LUAD	TCGA	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1667
p.S362W	DO25113	LUAD	ICGC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1667
p.Q364H	TCGA-AP-A051	UCEC	TCGA	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1111
p.Q364H	DO42673	UCEC	ICGC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1111
p.V462L	TCGA-EE-A3AA	SKCM	TCGA	PPGY	ITCH	452:455	Mutation rewiring degron network	0.1389
p.V462L	DO37571	SKCM	ICGC	PPGY	ITCH	452:455	Mutation rewiring degron network	0.1389
p.P365L	TCGA-FA-A6HN	DLBC	TCGA	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.0833
p.P365L	DO219887	DLBC	ICGC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.0833
p.P341L	DO220853	MELA	ICGC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.0556
p.S342F	DO222696	MELA	ICGC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation blocking phosphorylation signal	0.5278
p.S342F	SIDM01590	Breast Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation blocking phosphorylation signal	0.5278
p.E344A	SIDM02039	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1389
p.P357S	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.3056
p.P357S	SIDM01409	Bladder Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.3056
p.P350S	SIDM00879	Breast Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.3056
p.P350R	SIDM00136	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.3056
p.P350R	HT-29	large intestine	COSMIC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.3056
p.A457S	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	452:455	Mutation rewiring degron network	0.2778
p.A457S	SIDM00221	Melanoma	GDSC	PPGY	ITCH	452:455	Mutation rewiring degron network	0.2778
p.A457S	SIDM01760	Rhabdomyosarcoma	GDSC	PPGY	ITCH	452:455	Mutation rewiring degron network	0.2778
p.G454S	SIDM00221	Melanoma	GDSC	PPGY	ITCH	452:455	Mutation altering degron motif	0.5882
p.E344K	SIDM00217	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1389
p.E344K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1389
p.E344K	SNU-1040	large intestine	COSMIC	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.1389
p.P452T	ACH-000019	Breast Cancer	CCLE	PPGY	ITCH	452:455	Mutation altering degron motif	0.7031
p.P452T	ACH-000028	Breast Cancer	CCLE	PPGY	ITCH	452:455	Mutation altering degron motif	0.7031
p.P444S	ACH-000223	Breast Cancer	CCLE	PPGY	ITCH	452:455	Mutation rewiring degron network	0.1111
p.P444S	HCC1937	breast	COSMIC	PPGY	ITCH	452:455	Mutation rewiring degron network	0.1111
p.P365T	ACH-000290	Lung Cancer	CCLE	DSGMSS	DEG_SCF_TRCP1_1	351:356	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ESPN

UniProt ID: B1AK53

Entrez ID: 83715

Protein name: Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ESPN in