DegronMD

Uniprot ID: B1AK53

Source protein: Espin

Source gene: ESPN

Class: DEG_SCF_TRCP1_1

Location: 351:356

E3 ligase: BTRC

DEGRON score: 0.9705

ASA_SCORE: 29.2667

COIL: 0.7663

CONS_SCORE: 0.7193

DSS_SCORE: 0.6519

HELIX: 0.153

FCONS_SCORE: 1.1918

RIG_SCORE: 0.5452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S362W	TCGA-93-8067	LUAD	TCGA	DSGMSS	DEG_SCF_TRCP1_1	0.1667
p.S362W	DO25113	LUAD	ICGC	DSGMSS	DEG_SCF_TRCP1_1	0.1667
p.Q364H	TCGA-AP-A051	UCEC	TCGA	DSGMSS	DEG_SCF_TRCP1_1	0.1111
p.Q364H	DO42673	UCEC	ICGC	DSGMSS	DEG_SCF_TRCP1_1	0.1111
p.P365L	TCGA-FA-A6HN	DLBC	TCGA	DSGMSS	DEG_SCF_TRCP1_1	0.0833
p.P365L	DO219887	DLBC	ICGC	DSGMSS	DEG_SCF_TRCP1_1	0.0833
p.P341L	DO220853	MELA	ICGC	DSGMSS	DEG_SCF_TRCP1_1	0.0556
p.S342F	DO222696	MELA	ICGC	DSGMSS	DEG_SCF_TRCP1_1	0.5278
p.S342F	SIDM01590	Breast Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.5278
p.E344A	SIDM02039	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.1389
p.P357S	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.3056
p.P357S	SIDM01409	Bladder Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.3056
p.P350S	SIDM00879	Breast Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.3056
p.P350R	SIDM00136	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.3056
p.P350R	HT-29	large_intestine	COSMIC	DSGMSS	DEG_SCF_TRCP1_1	0.3056
p.E344K	SIDM00217	Colorectal Carcinoma	GDSC	DSGMSS	DEG_SCF_TRCP1_1	0.1389
p.E344K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMSS	DEG_SCF_TRCP1_1	0.1389
p.E344K	SNU-1040	large_intestine	COSMIC	DSGMSS	DEG_SCF_TRCP1_1	0.1389
p.P365T	ACH-000290	Lung Cancer	CCLE	DSGMSS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B1AK53	Espin	DEG_SCF_TRCP1_1	351:356	DSGMSS	BTRC	0.9705	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons