FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morp...
FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250|UniProtKB:A2AF47}.
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GO - Biological processes (BP):
B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]...
B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]
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GO - Molecular function (MF):
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]...
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
cytosol [GO:0005829]...
cytosol [GO:0005829]
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