DegronMD - Q7Z7L1(SLFN11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D266N	TCGA-22-4593	LUSC	TCGA	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.3056
p.D266N	DO27018	LUSC	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.3056
p.L396F	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1944
p.L396F	DO41235	UCEC	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1944
p.V400F	TCGA-AP-A1DK	UCEC	TCGA	PPGY	ITCH	401:404	Mutation rewiring degron network	0.3056
p.V400F	DO42033	UCEC	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.3056
p.L393I	TCGA-AX-A1CE	UCEC	TCGA	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1111
p.L393I	DO42280	UCEC	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1111
p.R272G	TCGA-CC-A7IE	LIHC	TCGA	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1389
p.R272G	DO52175	LIHC	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1389
p.R272G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1389
p.R272G	ACH-000937	Leukemia	CCLE	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1389
p.R272G	PF-382	haematopoietic and lymphoid tissue	COSMIC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1389
p.P401S	TCGA-EB-A3Y7	SKCM	TCGA	PPGY	ITCH	401:404	Mutation altering degron motif	0.6752
p.P401S	DO37499	SKCM	ICGC	PPGY	ITCH	401:404	Mutation altering degron motif	0.6752
p.E392K	TCGA-EE-A181	SKCM	TCGA	PPGY	ITCH	401:404	Mutation rewiring degron network	0.0833
p.E392K	DO37444	SKCM	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.0833
p.D251N	TCGA-EE-A29E	SKCM	TCGA	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.0556
p.D251N	DO37831	SKCM	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.0556
p.E263K	TCGA-EE-A3JD	SKCM	TCGA	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.E263K	DO11854	GBM	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.E263K	DO50299	SKCM	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.7022
p.L270F	TCGA-VS-A8QA	CESC	TCGA	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1944
p.L270F	DO51627	CESC	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1944
p.P402S	TCGA-WE-A8K5	SKCM	TCGA	PPGY	ITCH	401:404	Mutation altering degron motif	0.6752
p.P402S	DO51282	SKCM	ICGC	PPGY	ITCH	401:404	Mutation altering degron motif	0.6752
p.W413R	DO231992	LICA	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.0833
p.G259R	DO27857	MALY	ICGC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2778
p.R406Q	DO222749	MELA	ICGC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.2778
p.K253R	SIDM02063	Colorectal Carcinoma	GDSC	AKENV	DEG_APCC_KENBOX_2	261:265	Mutation blocking ubiquitination signal	0.5556
p.L412I	SIDM00871	Non-Cancerous	GDSC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1111
p.L412I	SIDM00872	Breast Carcinoma	GDSC	PPGY	ITCH	401:404	Mutation rewiring degron network	0.1111

Kaplan plot for SLFN11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLFN11

UniProt ID: Q7Z7L1

Entrez ID: 91607

Protein name: Schlafen family member 11 (EC 3.6.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLFN11 in