DegronMD

Uniprot ID: Q7Z7L1

Source protein: Schlafen family member 11

Source gene: SLFN11

Class: DEG_APCC_KENBOX_2

Location: 261:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6066

ASA_SCORE: 86.78

COIL: 0.7086

CONS_SCORE: 0.8634

DSS_SCORE: 0.3133

HELIX: 0.0408

FCONS_SCORE: 1.1599

RIG_SCORE: 0.7997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D266N	TCGA-22-4593	LUSC	TCGA	AKENV	DEG_APCC_KENBOX_2	0.3056
p.D266N	DO27018	LUSC	ICGC	AKENV	DEG_APCC_KENBOX_2	0.3056
p.R272G	TCGA-CC-A7IE	LIHC	TCGA	AKENV	DEG_APCC_KENBOX_2	0.1389
p.R272G	DO52175	LIHC	ICGC	AKENV	DEG_APCC_KENBOX_2	0.1389
p.R272G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	AKENV	DEG_APCC_KENBOX_2	0.1389
p.R272G	ACH-000937	Leukemia	CCLE	AKENV	DEG_APCC_KENBOX_2	0.1389
p.R272G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	AKENV	DEG_APCC_KENBOX_2	0.1389
p.D251N	TCGA-EE-A29E	SKCM	TCGA	AKENV	DEG_APCC_KENBOX_2	0.0556
p.D251N	DO37831	SKCM	ICGC	AKENV	DEG_APCC_KENBOX_2	0.0556
p.E263K	TCGA-EE-A3JD	SKCM	TCGA	AKENV	DEG_APCC_KENBOX_2	0.7022
p.E263K	DO11854	GBM	ICGC	AKENV	DEG_APCC_KENBOX_2	0.7022
p.E263K	DO50299	SKCM	ICGC	AKENV	DEG_APCC_KENBOX_2	0.7022
p.L270F	TCGA-VS-A8QA	CESC	TCGA	AKENV	DEG_APCC_KENBOX_2	0.1944
p.L270F	DO51627	CESC	ICGC	AKENV	DEG_APCC_KENBOX_2	0.1944
p.G259R	DO27857	MALY	ICGC	AKENV	DEG_APCC_KENBOX_2	0.2778
p.K253R	SIDM02063	Colorectal Carcinoma	GDSC	AKENV	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7L1	Schlafen family member 11	DEG_APCC_KENBOX_2	261:265	AKENV	APC,CDC20,FZR1	0.6066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons