DegronMD - Q8TAB3(PCDH19)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A362T	TCGA-28-2513	GBM	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.3056
p.A362T	TCGA-QG-A5YX	COAD	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.3056
p.A362T	DO44093	COAD	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.3056
p.A362T	DO12766	GBM	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.3056
p.L904M	TCGA-AO-A128	BRCA	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.2778
p.L904M	DO5326	BRCA	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.2778
p.R376H	TCGA-AP-A059	UCEC	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0556
p.R376H	DO41361	UCEC	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0556
p.S903I	TCGA-AX-A1CE	UCEC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.S903I	DO42280	UCEC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.S907C	TCGA-CK-4947	COAD	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.8652
p.S907C	DO10076	COAD	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.8652
p.D375Y	TCGA-CQ-7071	HNSC	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0833
p.D375Y	DO49069	HNSC	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0833
p.A369T	TCGA-D1-A103	UCEC	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.25
p.A369T	DO42312	UCEC	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.25
p.F896L	TCGA-DA-A1HY	SKCM	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.0556
p.F896L	TCGA-Q1-A5R2	CESC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.0556
p.F896L	DO49003	CESC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.0556
p.F896L	DO37409	SKCM	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.0556
p.S903N	TCGA-EE-A29M	SKCM	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.S903N	DO37404	SKCM	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.S903R	TCGA-EO-A22X	UCEC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.S903R	DO43907	UCEC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation rewiring degron network	0.25
p.R372L	TCGA-ER-A19B	SKCM	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.R372L	DO47491	SKCM	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.V373A	TCGA-FI-A2D5	UCEC	TCGA	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1389
p.V373A	DO41331	UCEC	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1389
p.P364T	TCGA-FS-A1Z0	SKCM	TCGA	PPGY	ITCH	363:366	Mutation altering degron motif	0.7031
p.P364T	DO37431	SKCM	ICGC	PPGY	ITCH	363:366	Mutation altering degron motif	0.7031
p.E910K	TCGA-IR-A3LA	CESC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.591
p.E910K	DO44377	CESC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.591
p.D375A	DO222884	COCA	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0833
p.G365C	DO233747	GACA	ICGC	PPGY	ITCH	363:366	Mutation altering degron motif	0.6489
p.R372W	DO33063	PACA	ICGC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.R372W	SIDM00945	Colorectal Carcinoma	GDSC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.R372W	ACH-000895	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.R372W	CL-34	large intestine	COSMIC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1667
p.L355P	SIDM00282	Colorectal Carcinoma	GDSC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1111
p.L355P	ACH-000998	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1111
p.V371L	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1944
p.V371L	ACH-002214	Lymphoma	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1944
p.V371L	BC-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.1944
p.P364R	SIDM01770	Gastric Carcinoma	GDSC	PPGY	ITCH	363:366	Mutation altering degron motif	0.7512
p.S361R	SIDM01464	Pancreatic Carcinoma	GDSC	PPGY	ITCH	363:366	Mutation rewiring degron network	0.2778
p.S361R	ACH-000502	Pancreatic Cancer	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.2778
p.S359I	ACH-001029	Bone Cancer	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.2222
p.D375N	ACH-001369	Ovarian Cancer	CCLE	PPGY	ITCH	363:366	Mutation rewiring degron network	0.0833
p.G906R	COLO-792	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.7568
p.H909Y	SW684	soft tissue	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.6118
p.H909Y	MCC26	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.6118
p.H908Y	SW684	soft tissue	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.7229
p.H908Y	MCC26	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.7229
p.G907R	COLO-792	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	906:912	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH19

UniProt ID: Q8TAB3

Entrez ID: 57526

Protein name: Protocadherin-19

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDH19 in