DegronMD

Uniprot ID: Q8TAB3

Source protein: Protocadherin-19

Source gene: PCDH19

Class: DEG_SCF_TRCP1_1

Location: 906:912

E3 ligase: BTRC

DEGRON score: 0.9677

ASA_SCORE: 79.7

COIL: 0.8423

CONS_SCORE: 0.4685

DSS_SCORE: 0.6695

HELIX: 0.1073

FCONS_SCORE: 1.0141

RIG_SCORE: 0.5947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L904M	TCGA-AO-A128	BRCA	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.2778
p.L904M	DO5326	BRCA	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.2778
p.S903I	TCGA-AX-A1CE	UCEC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.S903I	DO42280	UCEC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.S907C	TCGA-CK-4947	COAD	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.8652
p.S907C	DO10076	COAD	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.8652
p.F896L	TCGA-DA-A1HY	SKCM	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.0556
p.F896L	TCGA-Q1-A5R2	CESC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.0556
p.F896L	DO49003	CESC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.0556
p.F896L	DO37409	SKCM	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.0556
p.S903N	TCGA-EE-A29M	SKCM	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.S903N	DO37404	SKCM	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.S903R	TCGA-EO-A22X	UCEC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.S903R	DO43907	UCEC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.25
p.E910K	TCGA-IR-A3LA	CESC	TCGA	DSGHEES	DEG_SCF_TRCP1_1	0.591
p.E910K	DO44377	CESC	ICGC	DSGHEES	DEG_SCF_TRCP1_1	0.591
p.G906R	COLO-792	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.7568
p.H909Y	SW684	soft_tissue	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.6118
p.H909Y	MCC26	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.6118
p.H908Y	SW684	soft_tissue	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.7229
p.H908Y	MCC26	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.7229
p.G907R	COLO-792	skin	COSMIC	DSGHEES	DEG_SCF_TRCP1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAB3	Protocadherin-19	DEG_SCF_TRCP1_1	906:912	DSGHEES	BTRC	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons