DegronMD - Q96PX1(RNF157)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R320W	TCGA-12-1597	GBM	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.R320W	DO12424	GBM	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.S485L	TCGA-17-Z026	LUAD	TCGA	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.1944
p.N481T	TCGA-23-2079	OV	TCGA	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.3056
p.N481T	DO27999	OV	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.3056
p.R320Q	TCGA-37-4135	LUSC	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.R320Q	DO233912	GACA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.R320Q	DO26806	LUSC	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.L332S	TCGA-AX-A2HD	UCEC	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.7667
p.L332S	DO42608	UCEC	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.7667
p.E480K	TCGA-CF-A1HS	BLCA	TCGA	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation altering degron motif	0.7022
p.E480K	DO486	BLCA	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation altering degron motif	0.7022
p.V466A	TCGA-CG-5721	STAD	TCGA	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0833
p.V466A	DO38192	STAD	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0833
p.S368Y	TCGA-D1-A16Y	UCEC	TCGA	PPGY	ITCH	361:364	Mutation rewiring degron network	0.2222
p.S368Y	DO41524	UCEC	ICGC	PPGY	ITCH	361:364	Mutation rewiring degron network	0.2222
p.E508K	TCGA-DV-A4W0	KIRC	TCGA	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.1944
p.E508K	DO219235	KIRC	ICGC	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.1944
p.V466I	TCGA-OR-A5JW	ACC	TCGA	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0833
p.M328I	TCGA-ZF-A9R4	BLCA	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.6507
p.M328I	DO219061	BLCA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.6507
p.L484W	DO234330	ESAD	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.2222
p.H354Y	DO233191	GACA	ICGC	PPGY	ITCH	361:364	Mutation rewiring degron network	0.1389
p.P318S	DO233728	GACA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0556
p.S513G	DO233865	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.0556
p.G470R	DO233941	GACA	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.1944
p.T498K	DO228835	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.3056
p.G474S	DO232026	LICA	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.3056
p.P355Q	DO229036	LICA	ICGC	PPGY	ITCH	361:364	Mutation rewiring degron network	0.1667
p.A489D	DO229037	LICA	ICGC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0833
p.A489D	DO229037	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.0556
p.P342L	DO50970	LICA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.S505F	DO222859	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.2778
p.S465L	SIDM00777	Colorectal Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0556
p.S465L	ACH-000360	Colon/Colorectal Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0556
p.S465L	NCI-H508	large intestine	COSMIC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.0556
p.A372D	SIDM00120	Prostate Carcinoma	GDSC	PPGY	ITCH	361:364	Mutation rewiring degron network	0.1111
p.A372D	ACH-000979	Prostate Cancer	CCLE	PPGY	ITCH	361:364	Mutation rewiring degron network	0.1111
p.A372D	DU-145	prostate	COSMIC	PPGY	ITCH	361:364	Mutation rewiring degron network	0.1111
p.T483A	SIDM00282	Colorectal Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.25
p.T483A	ACH-000998	Colon/Colorectal Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.25
p.T483A	CW-2	large intestine	COSMIC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.25
p.E480G	SIDM00383	Gastric Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation altering degron motif	0.7199
p.E480G	ACH-002198	Gastric Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation altering degron motif	0.7199
p.E480G	SCH	stomach	COSMIC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation altering degron motif	0.7199
p.R326G	SIDM00148	Breast Carcinoma	GDSC	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2778
p.L484F	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.2222
p.L484F	ACH-000735	Head and Neck Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	475:480	Mutation rewiring degron network	0.2222
p.P507Q	ACH-000773	Lymphoma	CCLE	PLSST	DEG_SPOP_SBC_1	499:503	Mutation rewiring degron network	0.2222
p.T338A	ACH-001560	Lung Cancer	CCLE	MRKKLGPLS	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2778

Kaplan plot for RNF157 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF157

UniProt ID: Q96PX1

Entrez ID: 114804

Protein name: E3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF157 in