DegronMD

Uniprot ID: Q96PX1

Source protein: E3 ubiquitin ligase RNF157

Source gene: RNF157

Class: DEG_SCF_FBW7_2

Location: 475:480

E3 ligase: FBXW7

DEGRON score: 0.5301

ASA_SCORE: 89.2

COIL: 0.6378

CONS_SCORE: 0.3033

DSS_SCORE: 0.5607

HELIX: 0.3442

FCONS_SCORE: 1.045

RIG_SCORE: 0.6954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S485L	TCGA-17-Z026	LUAD	TCGA	VTPESE	DEG_SCF_FBW7_2	0.1944
p.N481T	TCGA-23-2079	OV	TCGA	VTPESE	DEG_SCF_FBW7_2	0.3056
p.N481T	DO27999	OV	ICGC	VTPESE	DEG_SCF_FBW7_2	0.3056
p.E480K	TCGA-CF-A1HS	BLCA	TCGA	VTPESE	DEG_SCF_FBW7_2	0.7022
p.E480K	DO486	BLCA	ICGC	VTPESE	DEG_SCF_FBW7_2	0.7022
p.V466A	TCGA-CG-5721	STAD	TCGA	VTPESE	DEG_SCF_FBW7_2	0.0833
p.V466A	DO38192	STAD	ICGC	VTPESE	DEG_SCF_FBW7_2	0.0833
p.V466I	TCGA-OR-A5JW	ACC	TCGA	VTPESE	DEG_SCF_FBW7_2	0.0833
p.L484W	DO234330	ESAD	ICGC	VTPESE	DEG_SCF_FBW7_2	0.2222
p.G470R	DO233941	GACA	ICGC	VTPESE	DEG_SCF_FBW7_2	0.1944
p.G474S	DO232026	LICA	ICGC	VTPESE	DEG_SCF_FBW7_2	0.3056
p.A489D	DO229037	LICA	ICGC	VTPESE	DEG_SCF_FBW7_2	0.0833
p.S465L	SIDM00777	Colorectal Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	0.0556
p.S465L	ACH-000360	Colon/Colorectal Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	0.0556
p.S465L	NCI-H508	large_intestine	COSMIC	VTPESE	DEG_SCF_FBW7_2	0.0556
p.T483A	SIDM00282	Colorectal Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	0.25
p.T483A	ACH-000998	Colon/Colorectal Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	0.25
p.T483A	CW-2	large_intestine	COSMIC	VTPESE	DEG_SCF_FBW7_2	0.25
p.E480G	SIDM00383	Gastric Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	0.7199
p.E480G	ACH-002198	Gastric Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	0.7199
p.E480G	SCH	stomach	COSMIC	VTPESE	DEG_SCF_FBW7_2	0.7199
p.L484F	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPESE	DEG_SCF_FBW7_2	0.2222
p.L484F	ACH-000735	Head and Neck Cancer	CCLE	VTPESE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PX1	E3 ubiquitin ligase RNF157	DEG_SCF_FBW7_2	475:480	VTPESE	FBXW7	0.5301	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons