DegronMD

Uniprot ID: Q96PX1

Source protein: E3 ubiquitin ligase RNF157

Source gene: RNF157

Class: DEG_APCC_DBOX_1

Location: 328:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8764

ASA_SCORE: 98.9556

COIL: 0.8302

CONS_SCORE: 0.2667

DSS_SCORE: 0.3444

HELIX: 0.0581

FCONS_SCORE: 0.6892

RIG_SCORE: 0.7134

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L332S	TCGA-AX-A2HD	UCEC	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	0.7667
p.L332S	DO42608	UCEC	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.7667
p.M328I	TCGA-ZF-A9R4	BLCA	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	0.6507
p.M328I	DO219061	BLCA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.6507
p.R326G	SIDM00148	Breast Carcinoma	GDSC	MRKKLGPLS	DEG_APCC_DBOX_1	0.2778
p.T338A	ACH-001560	Lung Cancer	CCLE	MRKKLGPLS	DEG_APCC_DBOX_1	0.2778
p.P342L	DO50970	LICA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.1667
p.R320W	TCGA-12-1597	GBM	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	0.1111
p.R320W	DO12424	GBM	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.1111
p.R320Q	TCGA-37-4135	LUSC	TCGA	MRKKLGPLS	DEG_APCC_DBOX_1	0.1111
p.R320Q	DO233912	GACA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.1111
p.R320Q	DO26806	LUSC	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.1111
p.P318S	DO233728	GACA	ICGC	MRKKLGPLS	DEG_APCC_DBOX_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PX1	E3 ubiquitin ligase RNF157	DEG_APCC_DBOX_1	328:336	MRKKLGPLS	APC,CDC20,FZR1	0.8764	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons